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1. (WO2016091347) COMBINATION OF A 6-OXO-1,6-DIHYDRO-PYRIDAZINE DERIVATIVE HAVING ANTI-CANCER ACTIVITY WITH A QUINAZOLINE DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/091347    International Application No.:    PCT/EP2015/002266
Publication Date: 16.06.2016 International Filing Date: 12.11.2015
IPC:
A61K 31/395 (2006.01), A61K 31/517 (2006.01), A61P 35/00 (2006.01)
Applicants: MERCK PATENT GMBH [DE/DE]; Frankfurter Strasse 250 64293 Darmstadt (DE)
Inventors: BLADT, Friedhelm; (DE).
FRIESE-HAMIM, Manja; (DE)
Priority Data:
14004186.4 11.12.2014 EP
Title (EN) COMBINATION OF A 6-OXO-1,6-DIHYDRO-PYRIDAZINE DERIVATIVE HAVING ANTI-CANCER ACTIVITY WITH A QUINAZOLINE DERIVATIVE
(FR) ASSOCIATION D'UN DÉRIVÉ DE 6-OXO-1,6-DIHYDRO-PYRIDAZINE AYANT UNE ACTIVITÉ ANTICANCÉREUSE AVEC UN DÉRIVÉ DE QUINAZOLINE
Abstract: front page image
(EN)A pharmaceutical composition of 3-(1-{3-[5-(1-Methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile or a pharmaceutically acceptable salt and/or solvate thereof in combination with 4-[(S)-2-azetidin-1-yl-1-(4-chloro-3-trifluoromethyl-phenyl)-ethylamino]-quinazoline-8-carboxylic acid amide.
(FR)L'invention concerne une composition pharmaceutique de 3-(1-{3-[5-(1-méthyl-pipéridin-4-ylméthoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile, ou d'un sel et/ou d'un solvate pharmaceutiquement acceptables de celui-ci, en association avec un amide d'acide 4-[(S)-2-azétidin-1-yl-1-(4-chloro-3-trifluorométhyl-phényl)-éthylamino]- quinazoline-8-carboxylique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)