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1. (WO2016090271) TREATMENT OF LEUKEMIA VIA THE ADMINISTRATION OF DOT1L INHIBITOR PINOMETOSTAT.
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/090271    International Application No.:    PCT/US2015/064038
Publication Date: 09.06.2016 International Filing Date: 04.12.2015
IPC:
A61K 31/52 (2006.01), A61P 35/02 (2006.01)
Applicants: EPIZYME, INC. [US/US]; 400 Technology Square 4th Floor Cambridge, Massachusetts 02139 (US)
Inventors: POLLOCK, Roy M.; (US).
DAIGLE, Scott R.; (US).
HEDRICK, Eric; (US).
WATERS, Nigel; (US).
THOMSON, Blythe; (US)
Agent: ELRIFI, Ivor; (US)
Priority Data:
62/088,218 05.12.2014 US
62/203,283 10.08.2015 US
62/250,960 04.11.2015 US
62/251,529 05.11.2015 US
Title (EN) TREATMENT OF LEUKEMIA VIA THE ADMINISTRATION OF DOT1L INHIBITOR PINOMETOSTAT.
(FR) TRAITEMENT DE LA LEUCÉMIE PAR ADMINISTRATION DE L'INHIBITEUR DE DOT1L PINOMETOSTAT
Abstract: front page image
(EN)The present invention relates to a method for the treatment of leukemia and the induction of leukemic blast cell maturation or differentiation via the administration of the DOT1L inhibitor pinometostat (otherwise known as EPZ-5676; CAS Registry number 1380288-87-8) or its N-oxide or pharmaceutically acceptable salt thereof.
(FR)La présente invention concerne un procédé de traitement de la leucémie et d'induction de la maturation ou à la différentiation de cellules blastiques leucémiques par administration de l'inhibiteur de DOT1L pinometostat (également appelé EPZ-5676 ; numéro d'enregistrement CAS 1380288-87-8) ou de son N-oxyde ou d'un sel pharmaceutiquement acceptable de ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)