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1. (WO2016090263) SYSTEMS AND METHODS OF DISEASE MODELING USING STATIC AND TIME-DEPENDENT HYDROGELS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/090263    International Application No.:    PCT/US2015/064025
Publication Date: 09.06.2016 International Filing Date: 04.12.2015
IPC:
A61K 47/36 (2006.01), A61K 9/00 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 5th Floor Oakland, California 94607-5200 (US)
Inventors: ENGLER, Adam; (US)
Agent: NOVOM, Antony; (US)
Priority Data:
62/088,405 05.12.2014 US
Title (EN) SYSTEMS AND METHODS OF DISEASE MODELING USING STATIC AND TIME-DEPENDENT HYDROGELS
(FR) SYSTÈMES ET PROCÉDÉS DE MODÉLISATION DE MALADIE AU MOYEN D'HYDROGELS STATIQUES ET DÉPENDANT DU TEMPS
Abstract: front page image
(EN)Provided are methods and devices for the selection and regulation of the mechanical properties of substrates or tissue microenvironments as a technique to model disease progression in tissues. Substrate mechanical properties include elasticity, which is varied dynamically. Also provided are methods and devices for screening for compounds useful for treating such diseases.
(FR)La présente invention concerne des procédés et des dispositifs pour la sélection et la régulation des propriétés mécaniques de substrats ou de micro-environnements tissulaires en tant que technique pour modéliser la progression d'une maladie dans des tissus. Les propriétés mécaniques du substrat comprennent l'élasticité, qui est modifiée dynamiquement. L'invention concerne également des procédés et des dispositifs de criblage de composés utiles pour traiter de telles maladies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)