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1. (WO2016090103) BIODEGRADABLE THERMO-RESPONSIVE POLYMERS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/090103    International Application No.:    PCT/US2015/063669
Publication Date: 09.06.2016 International Filing Date: 03.12.2015
IPC:
C08F 16/02 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 412 Low Memorial Library 535 West 116th Street New York, NY 10027 (US)
Inventors: KOBERTSTEIN, Jeffrey, T.; (US).
SAMANTA, Sanjoy; (IN).
DE SILVA, Chathuranga; (US)
Agent: SUPERKO, Colleen; (US)
Priority Data:
62/087,404 04.12.2014 US
62/192,822 15.07.2015 US
62/087,407 04.12.2014 US
62/087,409 04.12.2014 US
Title (EN) BIODEGRADABLE THERMO-RESPONSIVE POLYMERS AND USES THEREOF
(FR) POLYMÈRES THERMORÉACTIFS BIODÉGRADABLES ET LEURS UTILISATIONS
Abstract: front page image
(EN)The invention provides for novel thermo-responsive polymers and compositions comprising the same. In some embodiments, the polymers are water soluble, pH-degradable and have tunable lower critical solution temperatures. Other aspects of the invention include micelles and gels comprising the thermo-responsive polymers and derivatives thereof, as well as methods of delivering therapeutic agents comprising administering a biodegradable gel or micelle comprising a polyacetal compound cross-linked with a linker.
(FR)La présente invention concerne de nouveaux polymères thermoréactifs et des compositions les comprenant. Dans certains modes de réalisation, les polymères sont hydrosolubles, dégradables en fonction du pH et présentent des températures de solution critique inférieures ajustables. D'autres aspects de l'invention comprennent des micelles et des gels comprenant les polymères thermoréactifs et leurs dérivés, ainsi que des procédés d'administration d'agents thérapeutiques comprenant l'administration d'un gel ou d'une micelle biodégradable comprenant un composé de polyacétal réticulé avec un lieur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)