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1. (WO2016090077) ACTIVIN-ACTRII ANTAGONISTS AND USES FOR TREATING ANEMIA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/090077    International Application No.:    PCT/US2015/063595
Publication Date: 09.06.2016 International Filing Date: 03.12.2015
IPC:
G01N 33/00 (2006.01), A61K 38/00 (2006.01)
Applicants: CELGENE CORPORATION [US/US]; 86 Morris Avenue Summit, NJ 07901 (US).
ACCELERON PHARMA INC. [US/US]; 128 Sidney Street Cambridge, MA 02139 (US)
Inventors: ATTIE, Kenneth, M.; (US).
ROVALDI, Christopher; (US).
LAADEM, Abderrahmane; (US)
Agent: GEORGE, Nikolaos, C.; (US)
Priority Data:
62/086,977 03.12.2014 US
62/088,478 05.12.2014 US
62/173,782 10.06.2015 US
62/153,872 28.04.2015 US
62/218,728 15.09.2015 US
Title (EN) ACTIVIN-ACTRII ANTAGONISTS AND USES FOR TREATING ANEMIA
(FR) ANTAGONISTES DE L'ACTIVINE-ACTRII ET LEURS UTILISATIONS POUR LE TRAITEMENT DE L'ANÉMIE
Abstract: front page image
(EN)Provided herein are methods for the treatment in a subject of anemia, anemia requiring RBC transfusion, low or intermediate- 1 -risk myelodysplastic syndromes (MDS), and/or non-proliferative chronic myelomonocytic leukemia (CMML) in any mammals wherein the methods comprise administration of Activin-ActRII signaling inhibitors to a subject in need of the treatment.
(FR)La présente invention concerne des méthodes pour le traitement de l'anémie chez un sujet, l'anémie nécessitant une transfusion de globules rouges (RBC), de syndromes myélodysplasiques (SMD) de faible rique ou intermédiaire 1, et/ou de la leucémie myélomonocytique chronique (CMML) non proliférative chez un quelconque mammifère, les méthodes comprenant l'administration d'inhibiteurs de signalisation de l'activine-ActRII à un sujet en attente du traitement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)