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1. (WO2016090034) METHODS FOR B CELL PRECONDITIONING IN CAR THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/090034    International Application No.:    PCT/US2015/063498
Publication Date: 09.06.2016 International Filing Date: 02.12.2015
IPC:
C07K 16/28 (2006.01), A61K 35/00 (2006.01), C07K 14/725 (2006.01), C07K 16/30 (2006.01), C07K 19/00 (2006.01), A61P 35/00 (2006.01), A61K 39/00 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35 4056 Basel (CH).
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, Suite 200 Philadelphia, PA 19104 (US).
BROGDON, Jennifer [US/US]; (US) (US only).
BEATTY, Gregory [US/US]; (US) (US only).
GLASS, David [US/US]; (US) (US only).
JUNE, Carl, H. [US/US]; (US) (US only).
MANNICK, Joan [US/US]; (US) (US only).
MILONE, Michael, C. [US/US]; (US) (US only).
MURPHY, Leon [US/US]; (US) (US only).
PLESA, Gabriela [US/US]; (US) (US only).
SONG, Huijuan [CN/CN]; (CN) (US only).
WU, Qilong [US/CN]; (CN) (US only)
Inventors: BROGDON, Jennifer; (US).
BEATTY, Gregory; (US).
GLASS, David; (US).
JUNE, Carl, H.; (US).
MANNICK, Joan; (US).
MILONE, Michael, C.; (US).
MURPHY, Leon; (US).
PLESA, Gabriela; (US).
SONG, Huijuan; (CN).
WU, Qilong; (CN)
Agent: MYERS, P., Louis; (US)
Priority Data:
PCT/CN2014/092892 03.12.2014 CN
Title (EN) METHODS FOR B CELL PRECONDITIONING IN CAR THERAPY
(FR) MÉTHODES DE PRÉ-CONDITIONNEMENT DE CELLULES B DANS UNE THÉRAPIE CAR
Abstract: front page image
(EN)The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to the methods of preconditioning a subject, e.g., by depleting B cells in combination with the use of a cell comprising a chimeric antigen receptor (CAR) that targets a tumor antigen as described herein. The methods for preconditioning the subject described herein include using a cell comprising a CAR that targets a B cell antigen as described herein.
(FR)L'invention concerne des compositions et des méthodes de traitement de maladies associées à l'expression d'un antigène tumoral tel que décrit. L'invention concerne également les méthodes de pré-conditionnement d'un sujet, par exemple par déplétion de cellules B combinée à l'utilisation d'une cellule comprenant un récepteur d'antigène chimère (CAR) ciblant un antigène tumoral tel que décrit. Les méthodes de pré-conditionnement du sujet décrit comprennent l'utilisation d'une cellule comprenant un CAR qui cible un antigène de cellule B tel que décrit.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)