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1. (WO2016089968) THERMOREVERSIBLE HYDROGELS FROM THE ARRESTED PHASE SEPARATION OF ELASTIN-LIKE POLYPEPTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/089968    International Application No.:    PCT/US2015/063382
Publication Date: 09.06.2016 International Filing Date: 02.12.2015
IPC:
A61L 27/22 (2006.01), A61L 31/04 (2006.01), C07K 14/00 (2006.01)
Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue Cambridge, MA 02139 (US)
Inventors: OLSEN, Bradley, David; (US).
GLASSMAN, Matthew, J.; (US).
AVERY, Reginald, K.; (US)
Agent: GORDON, Dana, M.; (US)
Priority Data:
62/086,496 02.12.2014 US
Title (EN) THERMOREVERSIBLE HYDROGELS FROM THE ARRESTED PHASE SEPARATION OF ELASTIN-LIKE POLYPEPTIDES
(FR) HYDROGELS THERMORÉVERSIBLES OBTENUS PAR LA SÉPARATION DE PHASE ARRÊTÉE DE POLYPEPTIDES DE TYPE ÉLASTINE
Abstract: front page image
(EN)Disclosed are elastin-like polypeptides (ELPs) that form hydrogels upon heating. In certain embodiments, the invention relates to a polypeptide with the generic sequence (XPAVG)n, wherein independently for each occurrence X can be any one of a number of different natural or unnatural amino acids, and n is chosen to determine the size of the protein. In certain embodiments, the polypeptide is artificially engineered and the invention relates to a method of engineering the polypeptide, for example, via biosynthesis. In certain embodiments, the invention relates to a composition, comprising a solvent; and any one of the polypeptides described herein.
(FR)L'invention concerne des polypeptides de type élastine (PTE) qui forment des hydrogels par chauffage. Les hydrogels comprenant les polypeptides ont des propriétés mécaniques, notamment un module d'élasticité et une ténacité à la rupture, nécessaires pour des applications de port de charge.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)