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1. (WO2016089872) HETEROBIFUNCTIONAL INHIBITORS OF E-SELECTINS AND CXCR4 CHEMOKINE RECEPTORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/089872    International Application No.:    PCT/US2015/063191
Publication Date: 09.06.2016 International Filing Date: 01.12.2015
IPC:
C07H 15/207 (2006.01), A61K 31/7034 (2006.01)
Applicants: GLYCOMIMETICS, INC. [US/US]; 9708 Medical Center Drive Rockville, MD 20850 (US)
Inventors: MAGNANI, John, L.; (US).
SARKAR, Arun, K.; (US).
PETERSON, John, M.; (US)
Agent: CHAPMAN, Ernest, F.; (US)
Priority Data:
62/087,085 03.12.2014 US
Title (EN) HETEROBIFUNCTIONAL INHIBITORS OF E-SELECTINS AND CXCR4 CHEMOKINE RECEPTORS
(FR) INHIBITEURS HÉTÉROBIFONCTIONNELS DES E-SÉLECTINES ET DES RÉCEPTEURS AUX CHIMIOKINES CXCR4
Abstract: front page image
(EN)Compounds, compositions, and methods for treatment and/or prevention of cancer and inflammatory diseases, and for releasing cells such as stem cells (e.g., bone marrow progenitor cells) into circulating blood and enhancing retention of the cells in the blood are disclosed. For example, heterobifunctional compounds that inhibit both E-selectins and CXCR4 chemokine receptors are described and pharmaceutical compositions comprising at least one of the same.
(FR)L'invention concerne des composés, des compositions et des méthodes utilisables en vue du traitement et/ou de la prévention du cancer et des maladies inflammatoires, ainsi que pour libérer des cellules telles que des cellules souches (par exemple des cellules précurseurs de la moelle osseuse) dans la circulation sanguine et pour augmenter la rétention de ces cellules dans le sang. L'invention concerne, par exemple, des composés hétérobifonctionnels qui inhibent à la fois les E-sélectines et les récepteurs aux chimiokines CXCR4 et des compositions pharmaceutiques comprenant au moins l'un de ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)