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1. (WO2016089866) RNA-GUIDED SYSTEMS FOR IN VIVO GENE EDITING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/089866    International Application No.:    PCT/US2015/063181
Publication Date: 09.06.2016 International Filing Date: 01.12.2015
IPC:
C12N 15/00 (2006.01), C12N 15/07 (2006.01), C12N 15/87 (2006.01), C12N 9/10 (2006.01), A61K 48/00 (2006.01)
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, Massachusetts 02138 (US)
Inventors: WAGERS, Amy J.; (US).
TABEBORDBAR, Mohammadsharif; (US).
CHEW, Wei Leong; (US).
CHURCH, George M.; (US)
Agent: IWANICKI, John P.; (US)
Priority Data:
62/085,785 01.12.2014 US
Title (EN) RNA-GUIDED SYSTEMS FOR IN VIVO GENE EDITING
(FR) SYSTÈMES GUIDÉS PAR ARN POUR L'ÉDITION DE GÈNE IN VIVO
Abstract: front page image
(EN)Methods of editing target nucleic acids are provided using a guide RNA and a Cas9 protein to excise exons in a target gene and where the edited gene is expressed to produce a truncated polypeptide.
(FR)L'invention concerne des méthodes d'édition d'acides nucléiques cibles à l'aide d'un ARN guide et d'une protéine Cas9 pour exciser des exons dans un gène cible, le gène édité étant exprimé pour produire un polypeptide tronqué.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)