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Machine translation
1. (WO2016089818) PROTEINS AND PROTEIN CONJUGATES WITH INCREASED HYDROPHOBICITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/089818    International Application No.:    PCT/US2015/063102
Publication Date: 09.06.2016 International Filing Date: 01.12.2015
IPC:
A61K 9/50 (2006.01), A61K 38/26 (2006.01)
Applicants: ANTRIABIO, INC. [US/US]; 1450 Infinite Drive Louisville, Colorado 80027 (US)
Inventors: ROSENDAHL, Mary S.; (US).
MANTRIPRAGADA, Sankaram B.; (US).
GOMEZ, Eliana B.; (US)
Agent: HSU, David D.; (US)
Priority Data:
62/086,294 02.12.2014 US
14/954,591 30.11.2015 US
14/954,701 30.11.2015 US
Title (EN) PROTEINS AND PROTEIN CONJUGATES WITH INCREASED HYDROPHOBICITY
(FR) PROTÉINES ET CONJUGUÉS DE PROTÉINE À HYDROPHOBICITÉ AUGMENTÉE
Abstract: front page image
(EN)Examples may include a method of making a protein-PEG conjugate salt with increased hydrophobicity. The method may include providing an aqueous protein solution. This aqueous protein solution may include a protein and a pH buffer. The method may also include reacting a polyethylene glycol with the protein to form a protein-PEG conjugate. The method may further include protonating an amino group on the protein-PEG conjugate with a hydrophobic organic acid in an organic phase. The protonation may form the protein-PEG conjugate salt having a hydrophobic anion that increases the hydrophobicity-PEG conjugate salt.
(FR)Des exemples de la présente invention peuvent comprendre un procédé de fabrication d'un sel de conjugué protéine-PEG à hydrophobicité augmentée. Le procédé peut comprendre la fourniture d’une solution aqueuse de protéine. Cette solution aqueuse de protéine peut comprendre une protéine et un tampon de pH. Le procédé peut comprendre en outre la réaction d’un polyéthylène glycol avec la protéine pour former un conjugué protéine-PEG. Le procédé peut comprendre en outre la protonation d’un groupe amino sur le conjugué protéine-PEG avec un acide organique hydrophobe dans une phase organique. La protonation peut former le sel de conjugué protéine-PEG sel ayant un anion hydrophobe qui augmente l'hydrophobicité du sel de conjugué de PEG.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)