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1. (WO2016089804) INHIBITORS OF EZH2
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/089804    International Application No.:    PCT/US2015/063075
Publication Date: 09.06.2016 International Filing Date: 01.12.2015
IPC:
C07D 401/14 (2006.01), A61K 31/4436 (2006.01), A61P 35/00 (2006.01)
Applicants: ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center Indianapolis, Indiana 46285 (US)
Inventors: GUO, Deqi; (US).
YU, Kuo-Long; (US)
Agent: TUCKER, Tina M.; (US)
Priority Data:
62/088,045 05.12.2014 US
Title (EN) INHIBITORS OF EZH2
(FR) INHIBITEURS DE LA PROTÉINE EZH2
Abstract: front page image
(EN)The present invention relates to compounds that inhibit activity of the histone lysine N-methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, such as hematologic and solid tumors.
(FR)La présente invention concerne des composés qui inhibent l'activité de l'histone lysine N-méthyltransférase, activateur de l'homologue Zeste 2 (EZH2), des compositions pharmaceutiques comprenant les composés et des méthodes d'utilisation des composés pour traiter un cancer, tel que des tumeurs hématologiques et solides.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)