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1. (WO2016089797) NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/089797    International Application No.:    PCT/US2015/063061
Publication Date: 09.06.2016 International Filing Date: 01.12.2015
IPC:
A01N 43/00 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
FISCHER, Christian [DE/US]; (US) (US only).
BOGEN, Stephane, L. [US/US]; (US) (US only).
CHILDERS, Matthew, L. [US/US]; (US) (US only).
LLINAS, Francesc Xavier Fradera [ES/US]; (US) (US only).
ELLIS, J. Michael [US/US]; (US) (US only).
ESPOSITE, Sara [US/US]; (US) (NZ, US only).
HONG, Qingmei [US/US]; (US) (US only).
HUANG, Chunhui [CN/US]; (US) (US only).
KIM, Alexander, J. [US/US]; (US) (NZ, US only).
LAMPE, John, W. [US/US]; (US) (NZ, US only).
MACHACEK, Michelle, R. [US/US]; (US) (US only).
MCMASTERS, Daniel, R. [US/US]; (US) (US only).
OTTE, Ryan, D. [US/US]; (US) (US only).
PARKER, Dann, L., Jr. [US/US]; (US) (US only).
REUTERSHAN, Michael [US/US]; (US) (US only).
SCIAMMETTA, Nunzio [GB/US]; (US) (US only).
SHAO, Pengcheng, P. [US/US]; (US) (US only).
SLOMAN, David, L. [US/US]; (US) (US only).
UJJAINWALLA, Feroze [US/US]; (US) (US only).
WHITE, Catherine [US/US]; (US) (US only).
WU, Zhicai [US/US]; (US) (US only).
YU, Yang [CN/US]; (US) (US only).
ZHAO, Kake [US/US]; (US) (US only).
GIBEAU, Craig [US/US]; (US) (US only).
BIFTU, Tesfaye [US/US]; (US) (NZ, US only).
BIJU, Purakkattle [US/US]; (US) (NZ, US only).
CHEN, Lei [CN/US]; (US) (NZ, US only).
CLOSE, Joshua [US/US]; (US) (NZ, US only).
FULLER, Peter, H. [US/US]; (US) (NZ, US only).
HUANG, Xianhai [CN/US]; (US) (NZ, US only).
PARK, Min, K. [US/US]; (US) (NZ, US only).
SIMOV, Vladimir [MK/US]; (US) (NZ, US only).
WITTER, David, J. [US/US]; (US) (NZ, US only).
ZHANG, Hongjun [CN/US]; (US) (NZ, US only)
Inventors: FISCHER, Christian; (US).
BOGEN, Stephane, L.; (US).
CHILDERS, Matthew, L.; (US).
LLINAS, Francesc Xavier Fradera; (US).
ELLIS, J. Michael; (US).
ESPOSITE, Sara; (US).
HONG, Qingmei; (US).
HUANG, Chunhui; (US).
KIM, Alexander, J.; (US).
LAMPE, John, W.; (US).
MACHACEK, Michelle, R.; (US).
MCMASTERS, Daniel, R.; (US).
OTTE, Ryan, D.; (US).
PARKER, Dann, L., Jr.; (US).
REUTERSHAN, Michael; (US).
SCIAMMETTA, Nunzio; (US).
SHAO, Pengcheng, P.; (US).
SLOMAN, David, L.; (US).
UJJAINWALLA, Feroze; (US).
WHITE, Catherine; (US).
WU, Zhicai; (US).
ZHAO, Kake; (US).
GIBEAU, Craig; (US).
BIFTU, Tesfaye; (US).
BIJU, Purakkattle; (US).
CHEN, Lei; (US).
CLOSE, Joshua; (US).
FULLER, Peter, H.; (US).
HUANG, Xianhai; (US).
PARK, Min, K.; (US).
SIMOV, Vladimir; (US).
WITTER, David, J.; (US).
ZHANG, Hongjun; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US)
Priority Data:
62/088,262 05.12.2014 US
Title (EN) NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
(FR) COMPOSÉS TRICYCLIQUES INNOVANTS SERVANT D'INHIBITEURS D'ENZYMES IDH MUTANTES
Abstract: front page image
(EN)The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
(FR)La présente invention concerne des composés tricycliques de formule (I) qui sont des inhibiteurs d'une ou plusieurs enzymes IDH mutantes : (I). La présente invention concerne également des utilisations des composés tricycliques de l'invention pour le traitement ou la prévention potentiels de cancers dans lesquels une ou plusieurs enzymes IDH mutantes sont impliquées. La présente invention concerne aussi des compositions contenant ces composés. La présente invention concerne également des utilisations de ces compositions pour la prévention ou le traitement potentiels de tels cancers.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)