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1. (WO2016089796) FORMULATION INHIBITING EFFECTS OF LOW ACID ENVIRONMENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/089796    International Application No.:    PCT/US2015/063060
Publication Date: 09.06.2016 International Filing Date: 01.12.2015
IPC:
C07D 487/14 (2006.01), A61P 27/06 (2006.01), A61K 9/10 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US).
ZHU, Lei [CN/US]; (US) (US only).
CEGIELNIK, Yvonne [US/US]; (US) (US only).
LU, Qun [US/US]; (US) (US only)
Inventors: ZHU, Lei; (US).
CEGIELNIK, Yvonne; (US).
LU, Qun; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US)
Priority Data:
62/087,607 04.12.2014 US
Title (EN) FORMULATION INHIBITING EFFECTS OF LOW ACID ENVIRONMENT
(FR) FORMULATION INHIBANT LES EFFETS D'UN ENVIRONNEMENT FAIBLEMENT ACIDE
Abstract: front page image
(EN)The present invention is directed to formulations comprising PVP polymer, a dispersion of a compound of Formula I (API):, and citric acid, which formulations mitigate the effects of coadministering the compound of Formula I with a proton pump inhibitor compound.
(FR)La présente invention concerne des formulations comprenant un polymère PVP, une dispersion d'un composé de formule I (principe actif pharmaceutique) : et de l'acide citrique, lesquelles formulations atténuent les effets de la coadministration du composé de formule I et d'un composé inhibiteur de la pompe à protons.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)