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1. (WO2016089766) COMPOSITIONS COMPRISING 2-((1-(2(4-FLUOROPHENYL)-2-OXOETHYL)PIPERIDIN-4-YL)METHYL)ISOINDOLIN-1-ONE FOR TREATING SCHIZOPHRENIA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/089766    International Application No.:    PCT/US2015/062985
Publication Date: 09.06.2016 International Filing Date: 30.11.2015
IPC:
C07D 401/06 (2006.01), A61P 25/00 (2006.01), A61K 9/00 (2006.01), A61K 31/454 (2006.01)
Applicants: MINERVA NEUROSCIENCES, INC. [US/US]; 1601 Trapelo Road Suite 284 Waltham, Massachusetts 02451 (US)
Inventors: LUTHRINGER, Remy; (US).
OKUYAMA, Masahiro; (JP).
NOEL, Nadine; (FR).
WERNER, Sandra; (FR)
Agent: ELRIFI, Ivor R.; (US)
Priority Data:
62/086,691 02.12.2014 US
62/248,071 29.10.2015 US
Title (EN) COMPOSITIONS COMPRISING 2-((1-(2(4-FLUOROPHENYL)-2-OXOETHYL)PIPERIDIN-4-YL)METHYL)ISOINDOLIN-1-ONE FOR TREATING SCHIZOPHRENIA
(FR) COMPOSITIONS CONTENANT DE LA 2-((1-(2(4-FLUOROPHÉNYL)-2-OXOÉTHYL)PIPÉRIDIN-4-YL)MÉTHYL)ISOINDOLIN-1-ONE POUR TRAITER LA SCHIZOPHRÉNIE
Abstract: front page image
(EN)The disclosure provides a novel polymorph of Compound (I):, 2-((l-(2-(4-Fluorophenyl)-2-oxoethyl)piperidin-4- yl)methyl)isoindolin-l-one monohydrochloride dihydrate, i.e., Form (A) of Compound (Ι)·ΗΟ·2Η2O. Pharmaceutical compositions comprising Form (A) of Compound (Ι)·ΗΟ·2Η2O and related methods of treatment are also disclosed.
(FR)La présente invention concerne un nouveau polymorphe du composé (I) : le dihydrate de monohydrochlorure de 2-((1-(2-(4-fluorophényl)-2-oxoéthyl)pipéridin-4-yl)méthyle)isoindolin-1-one, soit la forme (A) du composé (I) ΗCl·2Η2O. Des compositions pharmaceutiques contenant la forme (A) du composé (I) ΗCl·2Η2O et des méthodes associées de traitement sont également décrites.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)