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1. (WO2016089722) HYDROXYMETHYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/089722    International Application No.:    PCT/US2015/062889
Publication Date: 09.06.2016 International Filing Date: 30.11.2015
IPC:
C07D 401/04 (2006.01), A61P 43/00 (2006.01), A61K 31/445 (2006.01), A61P 19/02 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
KUDUK, Scott, D. [US/US]; (US) (NZ, US only).
LIVERTON, Nigel [GB/US]; (US) (NZ, US only).
LUO, Yunfu [CN/CN]; (CN) (NZ, US only)
Inventors: KUDUK, Scott, D.; (US).
LIVERTON, Nigel; (US).
LUO, Yunfu; (CN)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US)
Priority Data:
PCT/CN2014/092805 02.12.2014 CN
Title (EN) HYDROXYMETHYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS
(FR) ANTAGONISTES DES RÉCEPTEURS DES OREXINES DE TYPE PIPÉRIDINE HYDROXYMÉTHYLIQUE
Abstract: front page image
(EN)The present invention is directed to hydroxymethyl piperidine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
(FR)La présente invention concerne des composés de pipéridine hydroxyméthylique qui sont des antagonistes des récepteurs des orexines. La présente invention concerne également des utilisations des composés décrits ici dans la prévention ou le traitement potentiel de troubles et de maladies neurologiques et psychiatriques dans lesquels sont impliqués les récepteurs des orexines. La présente invention concerne aussi des compositions comprenant ces composés. La présente invention concerne, en outre, des utilisations de ces compositions dans le cadre de la prévention ou du traitement potentiel des maladies dans lesquelles sont impliqués les récepteurs des orexines.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)