WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2016089692) NON-HUMAN ANIMALS HAVING A HUMANIZED CLUSTER OF DIFFERENTIATION 47 GENE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/089692    International Application No.:    PCT/US2015/062614
Publication Date: 09.06.2016 International Filing Date: 25.11.2015
IPC:
A01K 67/027 (2006.01), G01N 33/50 (2006.01), C07K 14/705 (2006.01)
Applicants: REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road Tarrytown, NY 10591-6707 (US)
Inventors: GURER, Cagan; (US).
IOFFE, Ella; (US).
MUJICA, Alexander; (US).
THURSTON, Gavin; (US)
Agent: GROLZ, Edward, W.; (US)
Priority Data:
62/087,992 05.12.2014 US
Title (EN) NON-HUMAN ANIMALS HAVING A HUMANIZED CLUSTER OF DIFFERENTIATION 47 GENE
(FR) ANIMAUX NON HUMAINS POSSÉDANT UN GÈNE CD47 HUMANISÉ
Abstract: front page image
(EN)Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of an endogenous cluster of differentiation (CD) gene, in particular a humanization of a CD47 gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous CD47 gene so that said non-human animals express a CD47 polypeptide that includes a human portion and a non-human portion (e.g., a murine portion).
(FR)La présente invention concerne des animaux non humains et des procédés et des compositions permettant de les produire et de les utiliser, lesdits animaux non humains étant caractérisés par une humanisation d'un gène CD et, notamment, par une humanisation d'un gène CD47. Lesdits animaux non humains peuvent être décrits, dans certains modes de réalisation, comme présentant une modification génétique concernant un gène CD47 endogène, de sorte que lesdits animaux non humains expriment un polypeptide CD47 qui comprend une partie humaine et une partie non humaine (par exemple une partie murine).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)