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1. WO2016088834 - DIHYDRONAPHTHALENE DERIVATIVE

Publication Number WO/2016/088834
Publication Date 09.06.2016
International Application No. PCT/JP2015/084019
International Filing Date 03.12.2015
IPC
C07D 205/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
205Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
A61K 31/397 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
397having four-membered rings, e.g. azetidine
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
CPC
A61K 31/015
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
01Hydrocarbons
015carbocyclic
A61K 31/19
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
A61K 31/397
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
397having four-membered rings, e.g. azetidine
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 13/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
10of the bladder
Applicants
  • 小野薬品工業株式会社 ONO PHARMACEUTICAL CO., LTD. [JP]/[JP]
Inventors
  • 久須美 健介 KUSUMI, Kensuke
  • 倉田 晴登 KURATA, Haruto
  • 長縄 厚志 NAGANAWA, Atsushi
  • 小寺 泰代 KODERA, Yasuyo
  • 稲垣 裕一 INAGAKI, Yuichi
  • 滝澤 洋也 TAKIZAWA, Hiroya
  • ウォルフ マーク アラン WOLF, Mark Allan
  • レイカー ジョセフ RAKER, Joseph
Agents
  • 青木 篤 AOKI, Atsushi
Priority Data
62/087,33804.12.2014US
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) DIHYDRONAPHTHALENE DERIVATIVE
(FR) DÉRIVÉ DE DIHYDRONAPHTALÈNE
(JA) ジヒドロナフタレン誘導体
Abstract
(EN)
A compound shown by general formula (I) (in the formula, all of the symbols are as defined in the specification) has selective S1P5 receptor agonist activity due to having a linker from a phenyl group to a cyclic substituent in a dihydronaphthalene skeleton; i.e., due to having a short linker of one atom or less as L in general formula (I), and can therefore serve as an agent for the treatment of S1P5-mediated diseases, e.g., neurodegenerative diseases such as schizophrenia.
(FR)
L'invention concerne un composé représenté par la formule générale (I) (dans laquelle tous les symboles sont tels que définis dans la description) et doté d'une activité sélective d'agoniste du récepteur S1P5 en raison du fait qu'il comprend un lieur d'un groupe phényle à un substituant cyclique dans un squelette de dihydronaphtalène; c'est-à-dire que, comme il contient un lieur court d'un atome ou moins représenté par L dans la formule générale (I), le composé selon l'invention peut par conséquent être utilisé en tant qu'agent thérapeutique dans le traitement des maladies induites par S1P5, par exemple les maladies neurodégénératives telles que la schizophrénie.
(JA)
 一般式(I)(式中、すべての記号は明細書記載の通り。)で示される化合物は、ジヒドロナフタレン骨格において、そのフェニル基から環状置換基までのリンカー、すなわち、一般式(I)中Lとして、1原子以下の短いリンカーとすることによって、選択的なS1P5受容体作動活性を有することから、S1P介在性疾患、例えば、統合失調症等の神経変性疾患の治療剤となり得る。
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