WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2016088059) METHODS AND COMPOSITIONS USING KLOTHO VARIANT POLYPEPTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/088059    International Application No.:    PCT/IB2015/059294
Publication Date: 09.06.2016 International Filing Date: 02.12.2015
IPC:
C07K 14/50 (2006.01), C12N 9/24 (2006.01), A61K 38/00 (2006.01), C12N 15/62 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35 4056 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
GUO, Donglin [CN/US]; (US) (US only).
IBEBUNJO, Chikwendu [US/US]; (US) (US only)
Inventors: GUO, Donglin; (US).
IBEBUNJO, Chikwendu; (US)
Common
Representative:
NOVARTIS AG; Lichtstrasse 35 4056 Basel (CH)
Priority Data:
62/087,516 04.12.2014 US
Title (EN) METHODS AND COMPOSITIONS USING KLOTHO VARIANT POLYPEPTIDES
(FR) PROCÉDÉS ET COMPOSITIONS EMPLOYANT DES POLYPEPTIDES VARIANTS DE KLOTHO
Abstract: front page image
(EN)The present disclosure is directed to compositions and methods related to an alpha sKlotho variant or fragment, in which 1 to up to about 20 amino acids have been deleted from the C- terminus, optionally also having mutations at V563 and/or K795. The present disclosure also pertains to an alpha sKlotho polypeptide variant or fragment, having mutations at V563 and/or K795, wherein the polypeptide variant or fragment is full-length, or optionally 1 to up to about 20 amino acids have been deleted from the C-terminus. The present disclosure also pertains to fusion polypeptides comprising: (a) an alpha sKlotho, in which 1 to up to about 20 amino acids have been deleted from the C-terminus, optionally also having mutations at V563 and/or K795; (b) a linker; and (c) FGF23, optionally having a mutation at R179, C206 and/or C244, or (c) serum albumin.
(FR)La présente invention concerne des compositions et des procédés associés à un variant ou un fragment d'alpha sKlotho, dans lequel de 1 jusqu'à environ 20 acides aminés ont été délétés de l'extrémité C-terminale, comportant éventuellement également des mutations en V563 et/ou en K795. La présente invention concerne également un variant ou un fragment de polypeptide d'alpha sKlotho, comportant des mutations en V563 et/ou en K795, lequel variant ou fragment de polypeptide est de longueur totale, ou dont éventuellement 1 jusqu'à environ 20 acides aminés ont été délétés de l'extrémité C-terminale. La présente invention concerne également des polypeptides de fusion comprenant : (a) un alpha sKlotho, dans lequel 1 jusqu'à environ 20 acides aminés ont été délétés de l'extrémité C-terminale comportant éventuellement également des mutations en V563 et/ou en K795 ; (b) un lieur ; et (c) FGF23, comprenant éventuellement une mutation en R179, en C206 et/ou en C244, ou (c) de l'albumine sérique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)