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1. (WO2016087975) CD38 INHIBITORS AND METHODS OF TREATMENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/087975    International Application No.:    PCT/IB2015/058965
Publication Date: 09.06.2016 International Filing Date: 19.11.2015
IPC:
C07D 403/04 (2006.01)
Applicants: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED [GB/GB]; 980 Great West Road Brentford Middlesex TW8 9GS (GB)
Inventors: BECHERER, J. David; (US).
CADILLA, Rodolfo; (US).
DEATON, David Norman; (US).
HAFFNER, Curt; (US).
HENKE, Brad Richard; (US).
PREUGSCHAT, Frank; (US).
SCHULTE, Christie; (US)
Priority Data:
62/086,844 03.12.2014 US
Title (EN) CD38 INHIBITORS AND METHODS OF TREATMENT
(FR) INHIBITEURS DE LA CD38 ET MÉTHODES DE TRAITEMENT
Abstract: front page image
(EN)Compounds of Formula (I) and methods of treating diseases of metabolism by modulating cellular NAD+ levels through the inhibition of the CD38 enzyme, are disclosed. Formula (I).
(FR)L'invention concerne des composés de formule I et des méthodes de traitement de maladies du métabolisme, par modulation des niveaux de NAD+ cellulaire par inhibition de l'enzyme CD38. Formule I
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)