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1. (WO2016087651) HUMANIZED ANTI-TROP-2 MONOCLONAL ANTIBODIES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/087651    International Application No.:    PCT/EP2015/078672
Publication Date: 09.06.2016 International Filing Date: 04.12.2015
IPC:
C07K 16/30 (2006.01), A61K 39/395 (2006.01), A61P 35/00 (2006.01)
Applicants: ABRUZZO THERANOSTIC S.R.L. [IT/IT]; Via Garibaldi Vico XVII n. 15 66034 Lanciano (CH) (IT)
Inventors: GUERRA, Emanuela; (IT).
ALBERTI, Saverio; (IT)
Agent: CAPASSO, Olga; (IT)
Priority Data:
CH2014A000032 04.12.2014 IT
Title (EN) HUMANIZED ANTI-TROP-2 MONOCLONAL ANTIBODIES AND USES THEREOF
(FR) ANTICORPS MONOCLONAUX ANTI-PRÉ-TROP-2 HUMANISÉS ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention refers to humanized anti-Trop-2 antibodies and their fragments, derivatives and conjugates that are able to recognise and bind with high affinity distinct regions of the Trop-2 molecule. The present invention also teaches the use of such antibodies and of pharmaceutical compositions thereof for diagnosis and therapy of human pathologies, in particular cancer.
(FR)La présente invention concerne des anticorps anti-Trop-2 humanisés et leurs fragments, dérivés et conjugués qui sont capables de reconnaître et de se lier avec une grande affinité à régions distinctes de la molécule Trop-2. La présente invention concerne également l'utilisation de tels anticorps et de compositions pharmaceutiques les contenant pour le diagnostic et le traitement de pathologies humaines, en particulier le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)