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1. (WO2016087650) DOMAIN-EXCHANGED ANTIBODY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/087650    International Application No.:    PCT/EP2015/078670
Publication Date: 09.06.2016 International Filing Date: 04.12.2015
IPC:
C07K 16/00 (2006.01), C07K 16/28 (2006.01)
Applicants: MERCK PATENT GMBH [DE/DE]; Frankfurter Straße 250 64293 Darmstadt (DE)
Inventors: WOZNIAK-KNOPP, Gordana; (AT).
DIETRICH, Sylvia; (AT).
RÜKER, Florian; (AT).
GROSS, Alec W.; (US).
BECKER, Stefan; (DE)
Agent: REDL, Gerda; (AT)
Priority Data:
14196518.6 05.12.2014 EP
Title (EN) DOMAIN-EXCHANGED ANTIBODY
(FR) ANTICORPS À DOMAINE ÉCHANGÉ
Abstract: front page image
(EN)The invention provides for a domain-exchanged antibody comprising a light chain (LC) composed of VL-CH3, and a heavy chain (HC) comprising VH-CH3-CH2- CH3, wherein the VL-CH3 of the LC is dimerising with the VH-CH3 of the HC thereby forming a domain-exchanged LC/HC dimer comprising a CH3LC/CH3HC domain pair, and means and method for producing the same.
(FR)L'invention concerne un anticorps à domaine échangé comprenant une chaîne légère (LC) composée de VL-CH3, et une chaîne lourde (HC) comprenant VH-CH3-CH2-CH3, où VL-CH3 de la LC se dimérise avec VH-CH3 de la HC, ce qui permet de former un dimère LC/HC à domaine échangé comprenant une paire de domaines CH3LC/CH3HC, et un moyen et un procédé de production associé.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)