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Machine translation
1. (WO2016087338) 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/087338    International Application No.:    PCT/EP2015/077998
Publication Date: 09.06.2016 International Filing Date: 30.11.2015
IPC:
C07D 487/04 (2006.01), A61K 31/519 (2006.01), A61P 9/10 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE).
ASTRAZENECA UK LIMITED [GB/GB]; 2 Kingdom Street London W2 6BD (GB) (MG only)
Inventors: INGHARDT, Tord, Bertil; (SE).
TOMKINSON, Nicholas; (GB).
GAN, Li-Ming; (SE).
STONEHOUSE, Jeffrey, Paul; (US).
JOHANNESSON, Petra; (SE).
JURVA, Ulrik; (SE).
MICHAËLSSON, Erik; (SE).
LINDSTEDT-ALSTERMARK, Eva-Lotte; (SE)
Agent: STORM, Peter; AstraZeneca, Intellectual Property Milstein Building Granta Park Cambridge CB21 6GH (GB)
Priority Data:
62/085,722 01.12.2014 US
62/166,808 27.05.2015 US
Title (EN) 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE
(FR) 1-[2-(AMINOMÉTHYL)BENZYL]-2-THIOXO-1,2,3,5-TÉTRAHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES EN TANT QU'INHIBITEURS DE LA MYÉLOPEROXYDASE
Abstract: front page image
(EN)There are disclosed certain 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H- pyrrolo[3,2-d]pyrimidin-4-one compounds of formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of cardiovascular disorders such as heart failure and coronary artery disease related conditions.
(FR)L'invention concerne certains composés 1-[2-(aminométhyl)benzyl]-2-thioxo-1,2,3,5-tétrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one de formule (I), et des sels pharmaceutiquement acceptables de ces derniers, ainsi que des compositions les contenant et leur utilisation en thérapie. Les composés sont des inhibiteurs de l'enzyme MPO et sont donc particulièrement utiles dans le traitement ou la prophylaxie de troubles cardio-vasculaires tels que les affections liées à une insuffisance cardiaque et une coronaropathie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)