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1. (WO2016086403) METHOD OF DISTINGUISHING MESENCHYMAL STEM CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2016/086403 International Application No.: PCT/CN2014/093109
Publication Date: 09.06.2016 International Filing Date: 05.12.2014
IPC:
G01N 33/536 (2006.01) ,C12Q 1/68 (2006.01) ,C12N 5/0775 (2010.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
536
with immune complex formed in liquid phase
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775
Mesenchymal stem cells; Adipose-tissue derived stem cells
Applicants:
MERIDIGEN BIOTECH CO., LTD. [CN/CN]; 7F., No.68, Sec. 1, Neihu Rd. Neihu District Taipei City 114, Taiwan, CN
Inventors:
HSUAN, Chang-Yo; CN
LIU, Wei-Ting; CN
SHEN, Shih-Pei; CN
LIN, Yun; CN
LI, Yuan-Tsung; CN
CHANG, Chia-Chi; CN
Agent:
GE CHENG & CO., LTD.; Level 19, Tower E3, The Towers, Oriental Plaza, No.1, East Chang An Avenue Dongcheng District Beijing 100738, CN
Priority Data:
Title (EN) METHOD OF DISTINGUISHING MESENCHYMAL STEM CELLS
(FR) PROCÉDÉ DE DIFFÉRENCIATION DE CELLULES SOUCHES MÉSENCHYMATEUSES
Abstract:
(EN) A method of distinguishing mesenchymal stem cells (MSCs) in a primary culture of cells derived from a placenta-related tissue is provided. Also provided is a method of increasing the purity of MSC population in a primary culture of cells derived from a placenta-related tissue. Further provided is a method of isolating a MSC population which is more responsive in an inflammatory environment. Said methods each comprise a step of sorting the cells by a marker of EphA2.
(FR) L’invention concerne un procédé de différenciation de cellules souches mésenchymateuses (MSC) dans une culture primaire de cellules dérivées d’un tissu placentaire. L’invention concerne également un procédé d’accroissement de la pureté de la population de MSC dans une culture primaire de cellules dérivées d’un tissu placentaire. L’invention concerne en outre un procédé d’isolation d’une population de MSC qui répond mieux à un environnement inflammatoire. Une étape de chacun desdits procédés consiste à trier les cellules selon un marqueur d’EphA2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
SG11201703600YKR1020170071525CN106471371JP2018502556ID2018/01010