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1. (WO2016086092) CHEMICAL REPROGRAMMING OF HUMAN GLIAL CELLS INTO NEURONS FOR BRAIN AND SPINAL CORD REPAIR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/086092    International Application No.:    PCT/US2015/062594
Publication Date: 02.06.2016 International Filing Date: 25.11.2015
IPC:
C12N 5/00 (2006.01), C12N 5/071 (2010.01)
Applicants: THE PENN STATE RESEARCH FOUNDATION [US/US]; 304 Old Main University Park, PA 16802-7000 (US)
Inventors: CHEN, Gong; (US).
WU, Gang-yi; (US).
ZHANG, Lei; (US).
YIN, Jiu-chao; (US).
YEH, Hana; (US).
MA, Ning-xin; (US).
LEE, Grace; (US)
Agent: WATT, Rachel S.; (US)
Priority Data:
62/084,365 25.11.2014 US
62/215,828 09.09.2015 US
Title (EN) CHEMICAL REPROGRAMMING OF HUMAN GLIAL CELLS INTO NEURONS FOR BRAIN AND SPINAL CORD REPAIR
(FR) REPROGRAMMATION CHIMIQUE DE CELLULES GLIALES HUMAINES EN NEURONES POUR LA RÉPARATION DU CERVEAU ET DE LA MOELLE ÉPINIÈRE
Abstract: front page image
(EN)Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-β), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and γ-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG, purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN 193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.
(FR)L'invention concerne des procédés et des compositions de reprogrammation de cellules gliales humaines en neurones humains. La reprogrammation est obtenue à l'aide de combinaisons de composés qui peuvent modifier la signalisation, via les voies du facteur de croissance transformant bêta (TGF-β), de la protéine morphogénétique osseuse (PMO), de la glycogène synthase kinase 3 (GSK-3) et de la γ-secrétase/Notch. La reprogrammation est démontrée à l'aide de groupes de trois ou quatre composés qui sont choisis dans le groupe thiazovivine, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG, purmorphamine. La reprogrammation est démontrée à l'aide du groupe de LDN193189/CHIR99021/DAPT, du groupe de B431542/CHIR99021/DAPT, du groupe de LDN193189/DAPT/SB431542, du groupe de LDN193189/CHIR99021/SB431542, une combinaison de trois médicaments SB431542/CHIR99021/DAPT. L'invention concerne également la reprogrammation à l'aide d'analogues fonctionnels de ces composés, ainsi que des formulations pharmaceutiques qui contiennent les combinaisons de médicaments.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)