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1. (WO2016085302) COMPOSITION FOR INDUCING FACILITATION OF CELL REJUVENATION COMPRISING GENISTEIN OR EPIGALLOCATECHIN GALLATE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/085302    International Application No.:    PCT/KR2015/012881
Publication Date: 02.06.2016 International Filing Date: 27.11.2015
IPC:
A61K 31/352 (2006.01), A61K 31/353 (2006.01), A61K 8/49 (2006.01), A61P 17/00 (2006.01), A61Q 19/00 (2006.01)
Applicants: AMOREPACIFIC CORPORATION [KR/KR]; 106, Hangang-daero, Yongsan-gu, Seoul 140-777 (KR)
Inventors: LEE, Eun Kyung; (KR).
GOH, Myeong Jin; (KR).
CHOI, Hyun Jung; (KR).
CHO, Eun Gyung; (KR).
LEE, Tae Ryong; (KR)
Agent: KIM, Sun-young; (KR)
Priority Data:
10-2014-0168532 28.11.2014 KR
Title (EN) COMPOSITION FOR INDUCING FACILITATION OF CELL REJUVENATION COMPRISING GENISTEIN OR EPIGALLOCATECHIN GALLATE
(FR) COMPOSITION POUR INDUIRE LA FACILITATION DE RAJEUNISSEMENT CELLULAIRE COMPRENANT DE LA GÉNISTÉINE OU ÉPIGALLO-CATÉCHINE GALLATE
(KO) 제니스테인 또는 에피갈로카테친 갈레이트를 포함하는 세포 회춘 촉진 유도용 조성물
Abstract: front page image
(EN)The present description discloses a novel use of genistein and epigallocatechin gallate (EGCG), a derivative thereof, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, and a solvate thereof. A composition comprising genistein and EGCG, a derivative thereof, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof reduces the expression of a factor related to the increase of a melanin pigment forming ability, reduces the expression of a senescence marker protein, and adjusts the expression of an enzyme related to the formation of melanin pigments, and thus may have an effect of rejuvenating cells including melanin cells.
(FR)La présente invention concerne une nouvelle utilisation de génistéine et d'épigallo-catéchine gallate (EGCG), d'un dérivé correspondant, d'un isomère correspondant, d'un sel pharmaceutiquement acceptable correspondant, d'un promédicament correspondant, d'un hydrate correspondant et d'un solvate correspondant. Une composition comprenant de la génistéine et EGCG, un dérivé correspondant, un isomère correspondant, un sel pharmaceutiquement acceptable correspondant, un promédicament correspondant, un hydrate correspondant ou un solvate correspondant réduit l'expression d'un facteur lié à l'augmentation d'une capacité de formation de pigment de mélanine, réduit l'expression d'une protéine de marqueur de sénescence, et règle l'expression d'une enzyme liée à la formation de pigments de mélanine, et peut ainsi avoir un effet de rajeunissement de cellules comprenant des cellules de mélanine.
(KO)본 명세서에는 제니스테인(Genistein), 에피갈로카테친 갈레이트(Epigallocatechin gallate, EGCG), 이들의 유도체, 이들의 이성질체, 이들의 약학적으로 허용 가능한 염, 이들의 프로드럭, 이들의 수화물 및 이들의 용매화물의 신규한 용도가 개시된다. 상기 제니스테인, 에피갈로카테친 갈레이트, 이들의 유도체 이들의 이성질체, 이들의 약학적으로 허용 가능한 염, 이들의 프로드럭, 이들의 수화물 또는 이들의 용매화물을 포함하는 조성물은, 멜라닌 색소 형성능 증가 관련 인자의 발현을 감소시키고, 노화 지표 단백질의 발현을 감소시키며, 멜라닌 색소 형성 관련 효소의 발현을 조절함으로써, 멜라닌 세포를 포함하는 세포의 회춘 효과를 가질 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)