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1. (WO2016084412) B CELL ACTIVATION INHIBITOR, AND THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/084412    International Application No.:    PCT/JP2015/065466
Publication Date: 02.06.2016 International Filing Date: 28.05.2015
IPC:
A61K 38/00 (2006.01), A61K 39/395 (2006.01), A61K 47/42 (2006.01), A61K 47/48 (2006.01), A61P 5/16 (2006.01), A61P 9/00 (2006.01), A61P 19/02 (2006.01), A61P 21/00 (2006.01), A61P 21/04 (2006.01), A61P 25/00 (2006.01), A61P 25/02 (2006.01), A61P 29/00 (2006.01), A61P 31/22 (2006.01), A61P 37/02 (2006.01), A61P 37/06 (2006.01), A61P 43/00 (2006.01), C07K 14/475 (2006.01), C07K 19/00 (2006.01)
Applicants: THE UNIVERSITY OF TOKYO [JP/JP]; 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654 (JP).
CHUGAI SEIYAKU KABUSHIKI KAISHA [JP/JP]; 5-1, Ukima 5-chome, Kita-ku, Tokyo 1158543 (JP)
Inventors: FUJIO, Keishi; (JP).
OKAMURA, Tomohisa; (JP).
YAMAMOTO, Kazuhiko; (JP).
MORITA, Kaoru; (JP).
KOMAI, Toshihiko; (JP).
BAN, Nobuhiro; (JP).
MATSUURA, Tetsu; (JP).
NONAKA, Tatsuya; (JP)
Agent: HARUNA, Masao; (JP)
Priority Data:
2014-241193 28.11.2014 JP
Title (EN) B CELL ACTIVATION INHIBITOR, AND THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASES
(FR) INHIBITEUR D'ACTIVATION DES LYMPHOCYTES B, ET AGENT THÉRAPEUTIQUE POUR MALADIES AUTO-IMMUNES
(JA) B細胞活性化の抑制剤及び自己免疫疾患の治療剤
Abstract: front page image
(EN)It is found that the activation of a B cell can be inhibited by TGF-beta3 produced by LAG3+ Treg. A B cell activation inhibitor comprising TGF-beta3 or a molecule having the function of TGF-beta3 and a therapeutic agent for autoimmune diseases are discovered.
(FR)Selon l'invention, on a découvert que l'activation d'un lymphocyte B peut être inhibée par TGF-bêta3 produit par LLAG3+ Treg. On a également découvert un inhibiteur d'activation des lymphocytes B comprenant TGF-bêta3 ou une molécule ayant la fonction de TGF-bêta3 et un agent thérapeutique pour maladies auto-immunes.
(JA)LAG3+ Tregにより産生されたTGF-beta3により、B細胞活性化が抑制されることを見出した。またTGF-beta3又はTGF-beta3機能を有する分子を含むB細胞活性化の抑制剤および自己免疫疾患の治療剤を見出した。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)