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1. (WO2016082737) SUBSTITUTED THIOPHENE PYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/082737    International Application No.:    PCT/CN2015/095384
Publication Date: 02.06.2016 International Filing Date: 24.11.2015
IPC:
C07D 495/04 (2006.01), A61K 31/519 (2006.01), A61P 35/00 (2006.01)
Applicants: PEKING UNIVERSITY FOUNDER GROUP CO., LTD. [CN/CN]; No.298, Chengfu Rd Beijing 100871 (CN).
PKUCARE PHARMACEUTICAL R & D CENTER [CN/CN]; A106-109, Biotech Innovation Works, No.29 Life Science Park Road, Changping District Beijing 102206 (CN).
PKU HEALTHCARE INDUSTRY GROUP CO., LTD. [CN/CN]; 7th Floor, Zhongguancun Founder Building, 298 Chengfu Road Beijing 100871 (CN)
Inventors: YI, Chongqin; (CN).
XU, Heng; (CN).
HAN, Fangbin; (CN).
LIN, Songwen; (CN)
Agent: CCPIT PATENT AND TRADEMARK LAW OFFICE; 8th Floor, Vantone New World Plaza, 2 Fuchengmenwai Street, Xicheng District Beijing 100037 (CN)
Priority Data:
201410697475.0 27.11.2014 CN
Title (EN) SUBSTITUTED THIOPHENE PYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR
(FR) COMPOSÉ THIOPHÈNE PYRIMIDINE SUBSTITUÉ ET PROCÉDÉ DE PRÉPARATION DE CE COMPOSÉ
(ZH) 一种取代的噻吩并嘧啶化合物及其制备方法
Abstract: front page image
(EN)Disclosed are a substituted thiophene pyrimidine compound, a preparation method for the substituted thiophene pyrimidine compound, and usages of the substituted thiophene pyrimidine compound as a PI3-K and/or mTOR kinase inhibitor. The substituted thiophene pyrimidine compound and pharmaceutically acceptable salts thereof can be used to prepare medicines for treating and/or preventing tumorous diseases.
(FR)L'invention concerne un composé thiophène pyrimidine substitué, un procédé de préparation de ce composé thiophène pyrimidine substitué et des utilisations dudit composé thiophène pyrimidine substitué comme inhibiteur de la PI3-K kinase et/ou de la mTOR kinase. Ce composé thiophène pyrimidine substitué et ses sels pharmaceutiquement acceptables peuvent être utilisés pour préparer des médicaments pour le traitement et/ou la prévention de maladies tumorales.
(ZH)本发明公开了一种取代的噻吩并嘧啶化合物,以及它们的制备方法和其作为PI3-K和/或mTOR激酶抑制剂的用途。该取代的噻吩并嘧啶化合物及其药学上可接受的盐可用于制备治疗和/或预防肿瘤疾病的药物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)