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1. (WO2016082193) FULLY-HUMANIZED ANTI-HUMAN INTERLEUKIN 17A SINGLE-CHAIN ANTIBODY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/082193    International Application No.:    PCT/CN2014/092517
Publication Date: 02.06.2016 International Filing Date: 28.11.2014
IPC:
C07K 16/24 (2006.01), C12N 15/13 (2006.01), A61K 39/395 (2006.01), A61P 29/00 (2006.01), A61P 19/02 (2006.01), G01N 33/68 (2006.01)
Applicants: BEIJING INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES [CN/CN]; No.1,Xian Nong Tan Street, Xuanwu District Beijing 100050 (CN).
BEIJING WEIFENG YIMIN BIO-TECHNOLOGY LIMITED COMPANY, BEIJING, CHINA [CN/CN]; Room 1010, No.11 Chongwenmenwai Street, Dongcheng District, Beijing 100062 (CN)
Inventors: HU, Zhuowei; (CN).
SUN, Wei; (CN).
LIN, Heng; (CN).
MI, Su; (CN).
XIE, Jing; (CN)
Agent: BEIJING SAN GAO YONG XIN INTELLECTUAL PROPERTY AGENCY CO., LTD.; A-1-102, He Jing Yuan, Ji Men Li Xueyuan Road, Haidian District Beijing 100088 (CN)
Priority Data:
Title (EN) FULLY-HUMANIZED ANTI-HUMAN INTERLEUKIN 17A SINGLE-CHAIN ANTIBODY
(FR) ANTICORPS MONOCATÉNAIRE ENTIÈREMENT HUMANISÉ ANTI-INTERLEUKINE 17A HUMAINE
(ZH) 全人源抗人白介素17A单链抗体
Abstract: front page image
(EN)According to the present invention, by constructing a great-capacity natural phage antibody library, a single-chain antibody having specific affinity with IL-17A is obtained by biological elutriation. The antibody can inhibit the reaction of IL-17A on IL-6 released by a human fibrosarcoma cell HT1080 and can be used for detecting and treating rheumatoid arthritis.
(FR)Selon la présente invention, la construction d'une banque d'anticorps sur phages naturels de grande capacité permet d'obtenir un anticorps monocaténare ayant une affinité spécifique envers l'IL-17A par élutriation biologique. Cet anticorps peut inhiber la réaction de l'IL-17A sur l'IL-6 libérée par une cellule de fibrosarcome humain HT1080 et peut être utilisé pour dépister et traiter la polyarthrite rhumatoïde.
(ZH)本发明通过构建大容量天然噬菌体抗体库,通过生物淘洗获得对IL-17A具有特异亲和力的单链抗体。所述抗体能够抑制IL-17A对人纤维肉瘤细胞HT1080释放IL-6的反应,可用于检测和治疗类风湿性关节炎。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)