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1. (WO2016080853) 2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/080853 International Application No.: PCT/PT2015/050010
Publication Date: 26.05.2016 International Filing Date: 20.11.2015
IPC:
C07D 277/34 (2006.01) ,C07D 277/36 (2006.01) ,A61K 31/426 (2006.01) ,A61P 25/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
34
Oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36
Sulfur atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
426
1,3-Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
BSIM2 – BIOMOLECULAR SIMULATIONS LDA [PT/PT]; Biocant Park Parque Tecnologico de Cantanhede Nucleo 04; Lote 2; sala 2.11 3060-197 Cantanhede, PT
Inventors:
PONTES MEIRELES FERREIRA DE BRITO, Rui Manuel; PT
VIEIRA SIMÕES, Carlos Jose; PT
VASCONCELOS DIAS DE PINHO E MELO, Teresa Margarida; PT
DA SILVA VICTOR, Bruno Lourenço; PT
LOURENÇO DE ALMEIDA, Zaida Catarina; PT
CABRAL CARDOSO LOPES, Ana Lúcia; PT
OLIVEIRA NASCIMENTO, Bruno Filipe; PT
Agent:
VIEIRA PEREIRA FERREIRA, Maria Silvina; PT
Priority Data:
62/083,11821.11.2014US
Title (EN) 2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF
(FR) DÉRIVÉS DE 2-THIOXOTHIAZOLIDIN-4-ONE ACTIFS EN TANT QUE LIGANDS DE LA TRANSTHYRÉTINE ET UTILISATIONS DE CES DÉRIVÉS
Abstract:
(EN) Compounds of formula (II) are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).
(FR) L'invention concerne des composés de formule (II) utilisés pour stabiliser la protéine transthyrétine (TTR) et inhiber la formation de fibrilles amyloïdes, notamment la formation de fibrilles amyloïdes à médiation par la transthyrétine, et pour traiter, prévenir ou atténuer un ou plusieurs symptômes de maladies amyloïdes, telles que l'amyloïdose liée à la transthyrétine (ATTR).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)