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1. (WO2016079708) ANTIBODIES AGAINST SEROTONIN, TRYPTOPHAN AND KYNURENINE METABOLITES AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2016/079708 International Application No.: PCT/IB2015/058976
Publication Date: 26.05.2016 International Filing Date: 19.11.2015
IPC:
C07K 16/26 (2006.01) ,G01N 33/53 (2006.01) ,C07K 16/44 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
26
against hormones
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
44
against material not provided for elsewhere
Applicants:
NESTEC S.A. [CH/CH]; Avenue Nestlé 55 CH-1800 Vevey, CH
Inventors:
SELVARAJ, Fabiyola; US
PRINCEN, Fred; US
SINGH, Sharat; US
Priority Data:
62/082,04719.11.2014US
Title (EN) ANTIBODIES AGAINST SEROTONIN, TRYPTOPHAN AND KYNURENINE METABOLITES AND USES THEREOF
(FR) ANTICORPS DIRIGÉS CONTRE DES MÉTABOLITES DE SÉROTONINE, DE TRYPTOPHANE ET DE KYNURÉNINE ET LEURS UTILISATIONS
Abstract:
(EN) The present invention provides antibodies and methods for preparing antibodies to metabolites in the serotonin, tryptophan and kynurenine pathways, such as 5- hydroxyindole-3-acetic acid (5-HIAA), melatonin (MT) and kynurenic acid (KYNA). The specific metabolite antibodies have low cross-reactivity to structurally related metabolites, and are useful reagents for specific and sensitive immunoassays. The present invention also provides methods for using such antibodies to measure the levels of 5-HIAA, melatonin, or kynurenic acid in biological samples from human patients.
(FR) La présente invention concerne des anticorps et des procédés permettant de préparer des anticorps associés à des métabolites dans les voies de sérotonine, de tryptophane et de kynurénine, par exemple l'acide 5-hydroxyindole-3-acétique (5-HIAA), la mélatonine (MT) et l'acide kynurénique (KYNA). Les anticorps de métabolite spécifiques présentent une faible réactivité croisée à des métabolites structurellement associés, et sont des réactifs utiles pour des immunoessais spécifiques et sensibles. La présente invention concerne également des procédés permettant d'utiliser lesdits anticorps pour mesurer les niveaux de 5-HIAA, de mélatonine ou d'acide kynurénique dans des échantillons biologiques prélevés sur des patients humains.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2015348940SG11201703729RCA2968338IL252110CN107257805MX2017006537
JP2018501202KR1020170080701