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1. WO2016074203 - CELL APOPTOSIS INDUCER CONTAINING CHLORINE DIOXIDE AND USE THEREOF IN PREPARING COSMETICS OR ANTI-AGING OR ANTINEOPLASTIC DRUGS

Publication Number WO/2016/074203
Publication Date 19.05.2016
International Application No. PCT/CN2014/091047
International Filing Date 13.11.2014
IPC
A61K 33/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
A61K 47/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
12Carboxylic acids; Salts or anhydrides thereof
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 39/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39General protective or antinoxious agents
06Free radical scavengers or antioxidants
A61K 8/20 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
19containing inorganic ingredients
20Halogens; Compounds thereof
A61P 25/20 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
20Hypnotics; Sedatives
CPC
A61K 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
A61K 47/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
12Carboxylic acids; Salts or anhydrides thereof
A61K 8/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
19containing inorganic ingredients
20Halogens; Compounds thereof
A61Q 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
02for chemically bleaching or whitening the skin
A61Q 19/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
08Anti-ageing preparations
Applicants
  • 刘学武 LIU, Xuewu [CN]/[CN]
Inventors
  • 刘学武 LIU, Xuewu
Priority Data
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CELL APOPTOSIS INDUCER CONTAINING CHLORINE DIOXIDE AND USE THEREOF IN PREPARING COSMETICS OR ANTI-AGING OR ANTINEOPLASTIC DRUGS
(FR) INDUCTEUR D'APOPTOSE CELLULAIRE CONTENANT DU DIOXYDE DE CHLORE ET SON UTILISATION POUR PRÉPARER DES PRODUITS COSMÉTIQUES OU DES MÉDICAMENTS ANTI-VIEILLISSEMENT OU ANTI-NÉOPLASIQUES
(ZH) 包含二氧化氯的细胞凋亡诱导剂及其在制备化妆品或抗衰老或抗肿瘤药物中的用途
Abstract
(EN) The present invention relates to a cell apoptosis inducer containing chlorine dioxide. The present invention relates to a cell apoptosis inducer kit containing the following two independent components: the first component: a chlorine dioxide precursor solid, or a solution containing a chlorine dioxide precursor; and the second component: an auqeous solution of an acidity pH adjuster; the two components are stored separately, and can be mixed before use so that in-situ reaction occurs and the cell apoptosis inducer containing chlorine dioxide is prepared; and the amounts and concentrations of the first component and the second component enable the pH of the mixed solution to be 1.5-6.5. The present invention further relates to use of the cell apoptosis inducer containing chlorine dioxide or the cell apoptosis inducer kit containing chlorine dioxide in preparing drugs for treating tumors, or use thereof in preparing anti-aging drugs for target tissues of mammals, or use thereof as cosmetics, or use thereof in preparing chemotherapeutic drugs.
(FR) La présente invention concerne un inducteur d'apoptose cellulaire contenant du dioxyde de chlore. La présente invention concerne un nécessaire d'inducteur d'apoptose cellulaire contenant les deux constituants indépendants suivants : le premier constituant : un solide de précurseur de dioxyde de chlore ou une solution contenant un précurseur de dioxyde de chlore ; le second constituant : une solution aqueuse d'un agent d'ajustement d'acidité de pH ; les deux constituants sont stockés séparément et peuvent être mélangés avant leur utilisation, de telle façon qu'une réaction in situ se produit et l'inducteur d'apoptose cellulaire contenant du dioxyde de chlore est préparé ; les quantités et les concentrations du premier constituant et du second constituant permettent au pH de la solution mélangée d'être de 1,5 à 6.5. La présente invention concerne en outre l'utilisation de l'inducteur d'apoptose cellulaire contenant du dioxyde de chlore ou du nécessaire d'inducteur d'apoptose cellulaire contenant du dioxyde de chlore dans la préparation de médicaments pour traiter des tumeurs, ou son utilisation dans la préparation de médicaments anti-vieillissement pour des tissus cibles de mammifères, ou son utilisation comme produit cosmétique ou dans la préparation de médicaments chimiothérapeutiques.
(ZH) 涉及一种包含二氧化氯的细胞凋亡诱导剂。涉及一种细胞凋亡诱导剂试剂盒,其包含以下两种独立的组分:第一组分:二氧化氯前体固体,或包含二氧化氯前体的溶液;第二组分:酸性pH调节剂的水溶液;二者分开存放,且能在使用前进行混合,以现场反应并制得包含二氧化氯的细胞凋亡诱导剂;且第一组分和第二组分的量和浓度能够使得混合后的溶液的pH=1.5-6.5。还涉及包含二氧化氯的细胞凋亡诱导剂或包含二氧化氯的细胞凋亡诱导剂试剂盒用于制备治疗肿瘤的药物的用途,或者用于制备哺乳动物目标组织抗衰老药物的用途,或者用作化妆品的用途,或者用于制备化疗药物的用途。
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