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1. (WO2016071426) SYNTHESIS OF COPANLISIB AND ITS DIHYDROCHLORIDE SALT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2016/071426 International Application No.: PCT/EP2015/075765
Publication Date: 12.05.2016 International Filing Date: 05.11.2015
IPC:
C07D 487/04 (2006.01) ,C07D 233/24 (2006.01) ,C07D 295/088 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
04
having one double bond between ring members or between a ring member and a non-ring member
20
with substituted hydrocarbon radicals, directly attached to ring carbon atoms
24
Radicals substituted by nitrogen atoms not forming part of a nitro radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
295
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04
with substituted hydrocarbon radicals attached to ring nitrogen atoms
08
substituted by singly bound oxygen or sulfur atoms
084
with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
088
to an acyclic saturated chain
Applicants:
BAYER PHARMA AKTIENGESELLSCHAFT [DE/DE]; Müllerstr. 178 13353 Berlin, DE
Inventors:
PETERS, Jan-Georg; DE
STIEHL, Jürgen; DE
LOVIS, Kai; DE
Agent:
BIP PATENTS; c/o Bayer Intellectual Property GmbH Alfred-Nobel-Str. 10 40789 Monheim am Rhein, DE
Priority Data:
14192202.107.11.2014EP
Title (EN) SYNTHESIS OF COPANLISIB AND ITS DIHYDROCHLORIDE SALT
(FR) SYNTHÈSE DE COPANLISIB ET DE SON SEL DICHLORHYDRATE
Abstract:
(EN) The present invention relates to a novel method of preparing copanlisib, and copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib.
(FR) La présente invention concerne un nouveau procédé de préparation de copanlisib, et de dichlorhydrate de copanlisib, de nouveaux composés intermédiaires, et l'utilisation de ces nouveaux composés intermédiaires pour la préparation dudit copanlisib.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
UAa201705431AR102568AU2015341779CA2966796SG11201702999XMYPI 2017701571
MX2017005891EP3215507CN107074776IL251586US20170327505JP2017536352
TH170301EA201790982IN201717012933KR1020170078654ID2018/02958BR112017009471
ES2716730