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1. WO2016066758 - MILK PROTEIN HYDROLYSATE FOR USE IN THE TREATMENT OF DIARRHOEA

Publication Number WO/2016/066758
Publication Date 06.05.2016
International Application No. PCT/EP2015/075154
International Filing Date 29.10.2015
IPC
A61K 38/08 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61K 38/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61K 38/05 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
05Dipeptides
A61P 1/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
12Antidiarrhoeals
CPC
A23C 21/02
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
CDAIRY PRODUCTS, e.g. MILK, BUTTER, CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
21Whey; Whey preparations
02containing, or treated with, microorganisms or enzymes
A23L 33/18
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
17Amino acids, peptides or proteins
18Peptides; Protein hydrolysates
A23L 33/40
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
40Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
A23V 2002/00
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
2002Food compositions, function of food ingredients or processes for food or foodstuffs
A61K 38/018
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
01Hydrolysed proteins; Derivatives thereof
012from animals
018from milk
A61K 38/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
Applicants
  • LABORATORIOS ORDESA, S.L. [ES]/[ES]
Inventors
  • RIVERO URGELL, Montserrat
  • RODRÍGUEZ-PALMERO SEUMA, María
  • MORENO MUÑOZ, José Antonio
  • PUIGJANER RIBA, Joaquim
  • GARCÍA CRUZ, Marc
  • CIFUENTES ORJUELA, Gloria Clemencia
Agents
  • ZBM PATENTS - ZEA, BARLOCCI & MARKVARDSEN
Priority Data
14191179.230.10.2014EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MILK PROTEIN HYDROLYSATE FOR USE IN THE TREATMENT OF DIARRHOEA
(FR) HYDROLYSAT DE PROTÉINE DE LAIT DESTINÉ À ÊTRE UTILISÉ DANS LE TRAITEMENT DE LA DIARRHÉE
Abstract
(EN)
The invention relates to hydrolysates, which are for use in the treatment and/or prevention of diarrhoea. Said hydrolysates are capable of inhibiting neprilysin enzyme and obtainable by a method of producing a milk protein hydrolysate, said method comprising adding to a milk protein composition comprising whey protein and/or milk casein selected from the group consisting of beta-casein, alpha-casein and mixtures thereof, a protease system comprising a protease selected from neutral protease, alkaline protease, thermolysin, and mixtures thereof; and incubating at a constant pH and temperature to obtain an hydrolysate with a degree of hydrolysis (DH) of the composition from 1.0 to 40.0 %. The invention also relates to the new milk protein hydrolysates obtainable by said method and to nutritional and pharmaceutical compositions comprising it.
(FR)
L'invention concerne des hydrolysats, qui sont destinés à être utilisés dans le traitement et/ou la prévention de la diarrhée. Lesdits hydrolysats sont capables d'inhiber l'enzyme néprilysine et peuvent être obtenus par un procédé de production d'un hydrolysat de protéine de lait, ledit procédé comprenant l'ajout à une composition de protéine de lait comprenant la protéine de lactosérum et/ou la caséine de lait sélectionnée dans le groupe constitué de la bêta-caséine, de l'alpha-caséine, et de mélanges de celles-ci, d'un système de protéase comprenant une protéase sélectionnée parmi une protéase neutre, une protéase alcaline, la thermolysine, et des mélanges de celles-ci ; et l'incubation à un pH et à une température constante pour obtenir un hydrolysat avec un degré d'hydrolyse (DH) de la composition de 1,0 à 40,0 %. L'invention concerne également les nouveaux hydrolysats de protéine de lait pouvant être obtenus par ledit procédé et des compositions nutritionnelles et pharmaceutiques le comprenant.
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