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1. (WO2016065339) EFFICIENT OPTICAL ANALYSIS OF POLYMERS USING ARRAYS OF NANOSTRUCTURES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/065339 International Application No.: PCT/US2015/057245
Publication Date: 28.04.2016 International Filing Date: 23.10.2015
Chapter 2 Demand Filed: 24.08.2016
IPC:
C12Q 1/68 (2006.01) ,G01N 27/447 (2006.01) ,G01N 27/453 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27
Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26
by investigating electrochemical variables; by using electrolysis or electrophoresis
416
Systems
447
using electrophoresis
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27
Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26
by investigating electrochemical variables; by using electrolysis or electrophoresis
416
Systems
447
using electrophoresis
453
Cells therefor
Applicants: QUANTAPORE, INC.[US/US]; 1455 Adams Court, Suite 1081 Menlo Park, CA 94025, US
Inventors: HUBER, Martin; US
DAVIDSON, Stuart; US
Agent: BAGADE, Sanjay, S.; US
LEVINE, David, A.; US
Priority Data:
62/068,59924.10.2014US
Title (EN) EFFICIENT OPTICAL ANALYSIS OF POLYMERS USING ARRAYS OF NANOSTRUCTURES
(FR) ANALYSE OPTIQUE EFFICACE DE POLYMÈRES AU MOYEN DE RÉSEAUX DE NANOSTRUCTURES
Abstract:
(EN) The invention is directed to methods and apparatus for detecting sequences of optical signals from parallel reactions on an array of nanostructures, such as nanopores, nanowells, or nanoparticles. ln accordance with the invention, an array of nanostructures is provided, each nanostructure comprising a reaction site and each capable of confining a reaction that generates a sequence of optical signals, and the nanostructures of the array being arranged in clusters each comprising a number of nanostructures. Each different cluster is disposed within a different resolution limited area and the number of nanostructures in each cluster is either greater than one or a random variable with an average value greater than zero. Optical signals from reactions in the nanostructures are detected by an optical system operatively associated with the array.
(FR) L'invention concerne des procédés et un appareil pour détecter des séquences de signaux optiques issus de réactions en parallèle sur un réseau de nanostructures, telles que des nanopores, des nanopuits ou des nanoparticules. Selon l'invention, un réseau de nanostructures est fourni, chaque nanostructure comprenant un site de réaction et chacune pouvant confiner une réaction qui génère une séquence de signaux optiques, les nanostructures du réseau étant agencées en groupes comprenant chacun un certain nombre de nanostructures. Chaque groupe différent est disposé à l'intérieur d'une zone limitée de résolution différente et le nombre de nanostructures dans chaque groupe est soit supérieur à un, soit une variable aléatoire avec une valeur moyenne supérieure à zéro. Les signaux optiques issus des réactions dans les nanostructures sont détectés par un système optique associé de manière opérationnelle au réseau.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)