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|1. (WO2016065326) MODIFIED FGF-21 POLYPEPTIDES AND USES THEREOF|
|Applicants:||BRISTOL-MYERS SQUIBB COMPANY
|Inventors:||MORIN, Paul E.
REILLY, Timothy P.
CHRISTIAN, Rose C.
|Title:||MODIFIED FGF-21 POLYPEPTIDES AND USES THEREOF|
Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.