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1. (WO2016065326) MODIFIED FGF-21 POLYPEPTIDES AND USES THEREOF

Pub. No.:    WO/2016/065326    International Application No.:    PCT/US2015/057228
Publication Date: Fri Apr 29 01:59:59 CEST 2016 International Filing Date: Sat Oct 24 01:59:59 CEST 2015
IPC: A61K 38/00
C07K 14/50
Applicants: BRISTOL-MYERS SQUIBB COMPANY
Inventors: MORIN, Paul E.
COHEN, Daniel
MUKHERJEE, Ranjan
REILLY, Timothy P.
CHRISTIAN, Rose C.
LIPOVSEK, Dasa
CAMPHAUSEN, Ray
KRUPINSKI, John
Title: MODIFIED FGF-21 POLYPEPTIDES AND USES THEREOF
Abstract:
Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.