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Machine translation
1. (WO2016065326) MODIFIED FGF-21 POLYPEPTIDES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/065326    International Application No.:    PCT/US2015/057228
Publication Date: 28.04.2016 International Filing Date: 23.10.2015
IPC:
A61K 38/00 (2006.01), C07K 14/50 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 & Province Line Road Princeton, New Jersey 08543 (US)
Inventors: MORIN, Paul E.; (US).
COHEN, Daniel; (US).
MUKHERJEE, Ranjan; (US).
REILLY, Timothy P.; (US).
CHRISTIAN, Rose C.; (US).
LIPOVSEK, Dasa; (US).
CAMPHAUSEN, Ray; (US).
KRUPINSKI, John; (US)
Agent: TESKIN, Robin L.; (US)
Priority Data:
62/068,523 24.10.2014 US
62/068,514 24.10.2014 US
62/068,526 24.10.2014 US
62/068,534 24.10.2014 US
62/068,296 24.10.2014 US
62/141,337 01.04.2015 US
62/141,383 01.04.2015 US
Title (EN) MODIFIED FGF-21 POLYPEPTIDES AND USES THEREOF
(FR) POLYPEPTIDES FGF-21 MODIFIÉS ET LEURS UTILISATIONS
Abstract: front page image
(EN)Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.
(FR)La présente invention concerne des polypeptides FGF-21 modifiés et leurs utilisations, par exemple, pour le traitement de maladies associées à la fibrose. La présente invention concerne des polypeptides FGF-21 modifiés qui contiennent une délétion interne et éventuellement un peptide de remplacement, éventuellement modifiés avec au moins un acide aminé codé non naturellement, et/ou éventuellement fusionnés à un partenaire de fusion.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)