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1. (WO2016065252) NATIVE TRIMERIC ENV IMMUNOGEN DESIGN
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/065252 International Application No.: PCT/US2015/057098
Publication Date: 28.04.2016 International Filing Date: 23.10.2015
IPC:
A61P 31/18 (2006.01) ,A61K 31/711 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
18
for HIV
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
711
Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
Applicants:
INTERNATIONAL AIDS VACCINE INITIATIVE [US/US]; 125 Broad Street, 9th Floor New York, NY 10004, US
TRANSLATIONAL HEALTH SCIENCE & TECHNOLOGY INSTITUTE [IN/IN]; Udyog Vihar Phase III, Plot No. 496 Gurgaon, Haryana 122016, IN
Inventors:
CHAKRABARTI, Bimal, K.; IN
BOLIAR, Saikat; IN
DAS, Supratik; IN
SHRIVASTAVA, Tripti; IN
KING, Charles, Richter; US
BHATTACHARYA, Jayanta; IN
SAMAL, Sweety; IN
Agent:
KOWALSKI, Thomas, J.; US
Priority Data:
62/068,20224.10.2014US
62/155,67301.05.2015US
Title (EN) NATIVE TRIMERIC ENV IMMUNOGEN DESIGN
(FR) CONCEPTION D'UN IMMUNOGÈNE ENV TRIMÈRE NATIF
Abstract:
(EN) A major focus of HIV- 1 vaccine research is to design an immunogen that can elicit potent broadly neutralizing antibodies (bnAbs) to the envelope glycoproteins (Env). A clade C Env is disclosed that is stable and efficiently cleaved on the cell surface. Soluble forms of the Env are also disclosed. This Env exposes epitopes for many broadly neutralizing antibodies targeting distinct regions of the Env, while occludes those of non-neutralizing antibodies. Binding of several conformation dependent antibodies suggests that the Env assumes a native conformation on the cell surface and in soluble form. The efficient cleavage and antibody binding properties of the Env makes it a suitable immunogen to use in a vaccine and to serve as an effective platform for rational design of HIV- 1 vaccine immunogens.
(FR) La recherche en matière de vaccins contre le VIH-1 se concentre principalement sur la conception d'un immunogène pouvant susciter la production d'anticorps largement neutralisants efficaces contre les glycoprotéines d'enveloppe (Env). L'invention concerne une Env de clade C qui est stable et efficacement clivée de la surface cellulaire. Des formes solubles de cette Env sont également décrites. Cette Env met à nu des épitopes dirigés contre de nombreux anticorps largement neutralisant ciblant des zones distinctes de cette Env, tout en masquant ceux dirigés contre des anticorps non neutralisants. La liaison de plusieurs anticorps dépendant de la conformation suggère que cette Env adopte une conformation native à la surface des cellules et sous forme soluble. L'efficacité du clivage et des propriétés de liaison des anticorps de cette Env en font un immunogène approprié pour une utilisation dans un vaccin et pour servir de plate-forme efficace pour une conception rationnelle d'immunogènes pour le vaccin contre le VIH-1.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)