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1. (WO2016065142) NEW SCAFFOLDS AND MULTIFUNCTIONAL INTERMEDIATES FOR IMAGING PSMA AND CANCER THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/065142    International Application No.:    PCT/US2015/056909
Publication Date: 28.04.2016 International Filing Date: 22.10.2015
IPC:
C07D 249/04 (2006.01), A61K 49/10 (2006.01), A61K 49/06 (2006.01), A61K 51/04 (2006.01), A61K 47/48 (2006.01), A61P 35/00 (2006.01)
Applicants: THE JOHNS HOPKINS UNIVERSITY [US/US]; 3400 North Charles Street Baltimore, Maryland 21218 (US)
Inventors: POMPER, Martin G.; (US).
MEASE, Ronnie C.; (US).
RAY, Sangeeta; (US).
CHEN, Ying; (US).
YANG, Xing; (US)
Agent: CHILDERS, Jeffrey W.; (US)
Priority Data:
62/067,185 22.10.2014 US
Title (EN) NEW SCAFFOLDS AND MULTIFUNCTIONAL INTERMEDIATES FOR IMAGING PSMA AND CANCER THERAPY
(FR) NOUVEAUX ÉCHAFAUDAGES ET INTERMÉDIAIRES MULTIFONCTIONNELS POUR L'IMAGERIE DE ET LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express PSMA or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors that express PSMA or for photodynamic therapy.
(FR)L'invention concerne des échafaudages à base de carbamate et de bêta-aminoacide urée ayant une forte affinité de liaison à un PSMA. Ces échafaudages peuvent être radiomarqués et utilisés pour l'imagerie de cellules et de tumeurs qui expriment le PSMA ou pour la radiothérapie du cancer. Ces composés peuvent également comprendre un colorant fluorescent et être utilisés pour l'imagerie de cellules et de tumeurs qui expriment le PSMA ou pour la thérapie photodynamique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)