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1. (WO2016065138) THIAZOLYL-CONTAINING COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES

Pub. No.:    WO/2016/065138    International Application No.:    PCT/US2015/056899
Publication Date: Fri Apr 29 01:59:59 CEST 2016 International Filing Date: Fri Oct 23 01:59:59 CEST 2015
IPC: C07D 277/20
Applicants: DANA-FARBER CANCER INSTITUTE, INC.
Inventors: GRAY, Nathanael, S.
BUHRLAGE, Sara, Jean
TREON, Steven, P.
CHOI, Hwan, Geun
XIONG, Yuan
YANG, Guang
Title: THIAZOLYL-CONTAINING COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES
Abstract:
The present disclosure provides thiazolyl-containing compounds of Formula (I), (II), or (III). The compounds described herein may be able to inhibit protein kinases (e.g., Src family kinases (e.g., hemopoietic cell kinase (HCK)), Bruton' s tyrosine kinase (BTK)) and may be useful in treating and/or preventing proliferative diseases (e.g., myelodysplasia, leukemia, lymphoma (e.g., Waldenstrom's macroglobulinemia)) and in inducing apoptosis in a cell (e.g., malignant blood cell). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.