Exemplary apparatus and method can be provided for obtaining image information for at least one portion of at least one biological structure. For example, at least one housing comprising at least one channel can be used to contain the biological structure(s) that includes a first flowing structure and a second non-flowing structure. At least one illumination arrangement can be used to provide at least one first electro-magnetic radiation to the channel(s). At least one detector arrangement can be used to detect at least one second electro-magnetic radiation which is an interaction between the first structure, the second structure, the channel(s) and the first electro-magnetic radiation(s). At least one computer arrangement can be used to generate the image information regarding the portion(s) based on the second electro-magnetic radiation(s) and further information regarding at least one characteristic of the channel(s).