Search International and National Patent Collections

1. (WO2016065090) CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS

Pub. No.:    WO/2016/065090    International Application No.:    PCT/US2015/056794
Publication Date: Fri Apr 29 01:59:59 CEST 2016 International Filing Date: Fri Oct 23 01:59:59 CEST 2015
IPC: C07K 14/605
A61K 38/26
A61K 38/28
Applicants: MERCK SHARP & DOHME CORP.
CARRINGTON, Paul, E.
DENG, Qiaolin
NARGUND, Ravi
PALANI, Anandan
TUCKER, Thomas Joseph
WU, Chengwei
BIANCHI, Elisabetta
ORVIETO, Federica
PESSI, Antonello
Inventors: CARRINGTON, Paul, E.
DENG, Qiaolin
NARGUND, Ravi
PALANI, Anandan
TUCKER, Thomas Joseph
WU, Chengwei
BIANCHI, Elisabetta
ORVIETO, Federica
PESSI, Antonello
Title: CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS
Abstract:
Described are peptide analogs of glucagon, which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to have relatively balanced agonist activity at the glucagon-like peptide 1 (GLP-1) receptor and the glucagon (GCG) receptor, and the use of such GLP-1 receptor/GCG receptor co-agonists for treatment of metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity