Search International and National Patent Collections

1. (WO2016064999) NOVEL CHO INTEGRATION SITES AND USES THEREOF

Pub. No.:    WO/2016/064999    International Application No.:    PCT/US2015/056653
Publication Date: Fri Apr 29 01:59:59 CEST 2016 International Filing Date: Thu Oct 22 01:59:59 CEST 2015
IPC: C12N 15/90
C12N 15/85
Applicants: REGENERON PHARMACEUTICALS, INC.
Inventors: SHEN, Ying
BURAKOV, Darya
CHEN, Gang
FANDL, James P.
Title: NOVEL CHO INTEGRATION SITES AND USES THEREOF
Abstract:
Expression-enhancing nucleotide sequences for eukaryotic expressions systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Genomic integration sites providing enhanced expression and methods of use thereof are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells.