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1. (WO2016064914) DIVERSION-RESISTANT OPIOID FORMULATIONS

Pub. No.:    WO/2016/064914    International Application No.:    PCT/US2015/056514
Publication Date: Fri Apr 29 01:59:59 CEST 2016 International Filing Date: Wed Oct 21 01:59:59 CEST 2015
IPC: A61K 31/485
A61P 25/04
Applicants: ELYSIUM THERAPEUTICS, INC.
Inventors: JENKINS, Thomas, E.
Title: DIVERSION-RESISTANT OPIOID FORMULATIONS
Abstract:
The present invention provides a composition comprising an opioid agonist, and a polymer-antagonist conjugate. The polymer-antagonist conjugate preferably does not hydrolyze upon administration to a patient, and does not bind to the opioid receptors. The covalent bond between the polymer and the antagonist in the conjugate is broken over a defined period of time to release the antagonist into the formulation. The released antagonist attenuates the liking of the agonist, thereby eliminating the incentive to the diversion of the medicines.