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1. (WO2016064899) METHODS AND COMPOSITIONS FOR ANTIBODY AND ANTIBODY-LOADED DENDRITIC CELL MEDIATED THERAPY

Pub. No.:    WO/2016/064899    International Application No.:    PCT/US2015/056497
Publication Date: Fri Apr 29 01:59:59 CEST 2016 International Filing Date: Wed Oct 21 01:59:59 CEST 2015
IPC: C12N 5/078
C12N 5/0784
A61K 39/395
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors: ENGLEMAN, Edgar George
CARMI, Yaron
Title: METHODS AND COMPOSITIONS FOR ANTIBODY AND ANTIBODY-LOADED DENDRITIC CELL MEDIATED THERAPY
Abstract:
Methods, compositions, and kits are provided for inducing an immune response in an individual (e.g., an individual having cancer). Aspects of the methods include administering an antibody composition having an allogeneic IgG antibody; and administering a treatment that activates antigen presenting cells. In some cases, the antibody composition includes polyclonal allogeneic IgG antibodies with a plurality of binding specificities. In some cases, the polyclonal antibodies are from sera pooled from 2 or more individuals. In some cases, the methods include administering an antigen presenting cell stimulatory agent. Aspects of the methods also include contacting an antigen presenting cell (dendritic cell (DC)) from an individual with a target antigen and an antibody composition having an allogeneic IgG antibody to produce a loaded APC, which can be used to induce an immune response in the individual. Aspects of the methods also include contacting a T cell of the individual with the loaded APC.