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1. (WO2016064884) MEASURING ANTIPLATELET ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/064884 International Application No.: PCT/US2015/056471
Publication Date: 28.04.2016 International Filing Date: 20.10.2015
IPC:
C12Q 1/56 (2006.01) ,G01N 33/48 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
56
involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
Applicants: MELALEUCA, INC.[US/US]; 4609 W. 65th S. Idaho Falls, Idaho 83402, US
Inventors: RABOVSKY, Alexander B.; US
FINK, Bruno; DE
Agent: FOLLETT, Angela D.; US
Priority Data:
62/066,11420.10.2014US
Title (EN) MEASURING ANTIPLATELET ACTIVITY
(FR) MESURE DE L'ACTIVITÉ ANTIPLAQUETTAIRE
Abstract:
(EN) Provided herein are methods and materials for assessing platelet activity and/or the ability of substances (e.g., small molecule compounds and compositions comprising the same) to inhibit or activate platelet activity. For example, this document provides methods and materials that can include (a) applying abnormal flow conditions (e.g., oscillatory shear stress) to a sample of platelets (e.g., a blood sample or platelet-rich plasma sample) to stimulate the platelets, and (b) assessing the activity of the platelets. In some embodiments, the activity of the platelets can be assessed by measuring the amount of superoxide radial or the rate and/or level of platelet aggregation within the sample.
(FR) La présente invention concerne des méthodes et des matériaux permettant d'évaluer l'activité plaquettaire et/ou la capacité de certaines substances (par exemple des composés à petites molécules et des compositions les contenant) à inhiber ou à activer l'activité des plaquettes. Par exemple, ce document concerne des méthodes et des matériaux qui peuvent consister à (a) appliquer des conditions d'écoulement anormales (par exemple un stress de cisaillement oscillatoire) à un échantillon de plaquettes (par exemple un échantillon de sang ou un échantillon de plasma riche en plaquettes) pour stimuler les plaquettes, et (b) évaluer l'activité des plaquettes. Dans certains modes de réalisation, l'activité des plaquettes peut être évaluée en mesurant la quantité de radical superoxyde ou la vitesse et/ou le niveau de l'agrégation plaquettaire dans l'échantillon.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)