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1. (WO2016064880) MODIFIED TEMPLATE-INDEPENDENT ENZYMES FOR POLYDEOXYNUCLEOTIDE SYSTHESIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/064880    International Application No.:    PCT/US2015/056467
Publication Date: 28.04.2016 International Filing Date: 20.10.2015
IPC:
C12N 15/54 (2006.01)
Applicants: MOLECULAR ASSEMBLIES, INC. [US/US]; 11025 Pallon Way San Diego, CA 92124-2706 (US)
Inventors: EFCAVITCH, William, J.; (US).
SYLVESTER, Juliesta, E.; (US)
Agent: MEYERS, Thomas, C.; (US)
Priority Data:
62/065,976 20.10.2014 US
Title (EN) MODIFIED TEMPLATE-INDEPENDENT ENZYMES FOR POLYDEOXYNUCLEOTIDE SYSTHESIS
(FR) ENZYMES INDÉPENDANTES DE LA MATRICE MODIFIÉES POUR LA SYNTHÈSE DE POLYDÉSOXYNUCLÉOTIDES
Abstract: front page image
(EN)The invention includes methods for identifying polymerases, such as modified terminal nucleotidyl transferases (TdT), that are capable of binding nucleotides comprising removable 3'- O-blocking moieties to a nucleic acid initiator, without the use of a template. The invention further includes the identified polymerases, and methods of using the polymerases for de novo synthesis of predetermined oligonucleotide sequences.
(FR)Cette invention concerne des procédés permettant d'identifier des polymérases, telles que des nucléotidyl-transférases terminales (TdT) modifiées, qui sont capables de lier des nucléotides comprenant des fragments de blocage 3'-O- séparables à un initiateur d'acide nucléique, sans recourir au brin matrice. L'invention comprend en outre les polymérases identifiées, et des procédés d'utilisation desdites polymérases pour la synthèse de novo de séquences d'oligonucléotides prédéfinies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)