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1. (WO2016064673) PROXIMITY BASED METHODS FOR SELECTION OF BINDING PARTNERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/064673    International Application No.:    PCT/US2015/055941
Publication Date: 28.04.2016 International Filing Date: 16.10.2015
IPC:
C04B 40/02 (2006.01)
Applicants: THE SCRIPPS RESEARCH INSTITUTE [US/US]; 10550 North Torrey Pines Road La Jolla, CA 92037 (US)
Inventors: LERNER, Richard, A.; (US).
ZHANG, Hongkai; (US).
XIE, Jia; (US)
Agent: FITTING, Thomas; (US)
Priority Data:
62/066,105 20.10.2014 US
Title (EN) PROXIMITY BASED METHODS FOR SELECTION OF BINDING PARTNERS
(FR) PROCÉDÉS BASÉS SUR LA PROXIMITÉ POUR LA SÉLECTION DE PARTENAIRES DE LIAISON
Abstract: front page image
(EN)The invention provides methods for identifying binding partners (e.g., peptide ligands) that binds to a target protein (e.g., a cellular receptor). The methods entail co-localized expression of the target protein and candidate binding partners, and selection of binding partners based on their proximity in the plasma membrane.
(FR)L'invention concerne des procédés permettant l'identification de partenaires de liaison (par exemple, des ligands peptidiques) qui se lient à une protéine cible (par exemple, un récepteur cellulaire) Les procédés consistent en la co-expression localisée de la protéine cible et des partenaires de liaison candidats, et en la sélection de partenaires de liaison sur la base de leur proximité dans la membrane plasmique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)