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1. (WO2016064672) ANALYZING A SAMPLE WITH A CONSTRUCT COMPRISING A FLUORESCENT MOIETY AND A MAGNETIC MOIETY

Pub. No.:    WO/2016/064672    International Application No.:    PCT/US2015/055930
Publication Date: Fri Apr 29 01:59:59 CEST 2016 International Filing Date: Sat Oct 17 01:59:59 CEST 2015
IPC: G01N 33/53
G01N 33/543
Applicants: ATWOOD, Christopher, Gordon
Inventors: ATWOOD, Christopher, Gordon
Title: ANALYZING A SAMPLE WITH A CONSTRUCT COMPRISING A FLUORESCENT MOIETY AND A MAGNETIC MOIETY
Abstract:
In one aspect, presence and/or level of an analyte within a sample is determined by use of a construct comprising a magnetic moiety and a fluorescent moiety. In one embodiment, the construct is magnetically migrated to a transparent surface and then dragged along the surface. In one aspect, an evanescent field is applied and changes in the diffusional or rotational properties of the fluorescent moiety as it migrates in and out of the evanescent field are measured by changes in its fluorescent emission, providing a measure of the interaction between the construct and a component of the sample.