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1. (WO2016064648) TISSUE-MIMICKING HYDROGEL COMPOSITIONS FOR BIOFABRICATION
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Pub. No.: WO/2016/064648 International Application No.: PCT/US2015/055699
Publication Date: 28.04.2016 International Filing Date: 15.10.2015
IPC:
C08L 5/00 (2006.01)
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
L
COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
5
Compositions of polysaccharides or of their derivatives not provided for in group C08L1/ or C08L3/142
Applicants:
WAKE FOREST UNIVERSITY HEALTH SCIENCES [US/US]; Medical Center Boulevard Winston-Salem, North Carolina 27157, US
Inventors:
SKARDAL, Aleksander; US
SOKER, Shay; US
Agent:
SIBLEY, Kenneth D.; US
Priority Data:
62/068,21824.10.2014US
Title (EN) TISSUE-MIMICKING HYDROGEL COMPOSITIONS FOR BIOFABRICATION
(FR) COMPOSITIONS D'HYDROGEL IMITANT UN TISSU POUR BIOFABRICATION
Abstract:
(EN) An extrudable hydrogel composition useful for making a three-dimensional organ construct includes a cross-linkable prepolymer, a post-deposition crosslinking group, optionally, an initiator that catalyzes the reaction between the prepolymer and said the crosslinking group; live cells (e.g., plant, animal, or microbial cells), optionally at least one one growth factor, and optionally water to balance. Methods of using the same and products so made are also described.
(FR) La présente invention concerne une composition extrudable d'hydrogel utile pour la fabrication d'une construction d'organe en trois dimensions qui comprend un prépolymère réticulable, un groupe de réticulation post-dépôt, éventuellement, un initiateur qui catalyse la réaction entre le prépolymère et ledit groupe de réticulation; des cellules vivantes (e.g., végétales, animales ou des cellules microbiennes), éventuellement au moins un facteur de croissance, le complément étant éventuellement constitué d’eau. L'invention décrit également ses procédés d'utilisation et des produits ainsi fabriqués.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)