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1. (WO2016063995) COMPOSITIONS AND METHODS FOR TREATING INSOMNIA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/063995    International Application No.:    PCT/JP2015/080304
Publication Date: 28.04.2016 International Filing Date: 21.10.2015
IPC:
A61K 31/506 (2006.01), A61P 25/20 (2006.01)
Applicants: EISAI R&D MANAGEMENT CO., LTD. [JP/JP]; 6-10 Koishikawa, 4-chome, Bunkyo-ku, Tokyo 1128088 (JP)
Inventors: MOLINE Margaret; (US).
PASTINO Gina; (US).
AKIMOTO Yurie; (JP).
ZAIMA Yasuhiro; (JP).
SUZUKI Nobuya; (JP).
YOSHIDA Nobuo; (JP)
Agent: SHIGA Masatake; 1-9-2, Marunouchi, Chiyoda-ku, Tokyo 1006620 (JP)
Priority Data:
62/067,443 23.10.2014 US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING INSOMNIA
(FR) COMPOSITIONS ET MÉTHODES POUR TRAITER L'INSOMNIE
Abstract: front page image
(EN)In the present invention, compound such as (lR,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.
(FR)Selon la présente invention, des composés tels que le (1R,2S)-2-(((2,4-diméthylpyrimidin-5-yl)oxy)méthyl)-2-(3-fluorophényl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide se sont révélés être de puissants antagonistes des récepteurs de l'orexine, et peuvent être utiles pour le traitement de troubles du sommeil, tels que l'insomnie, ainsi que pour d'autres utilisations thérapeutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)