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1. (WO2016063544) SOLID PHARMACEUTICAL COMPOSITION

Pub. No.:    WO/2016/063544    International Application No.:    PCT/JP2015/005344
Publication Date: Fri Apr 29 01:59:59 CEST 2016 International Filing Date: Sat Oct 24 01:59:59 CEST 2015
IPC: A61K 31/4709
A61K 9/20
A61P 31/04
Applicants: KYORIN PHARMACEUTICAL CO., LTD.
杏林製薬株式会社
Inventors: UCHIDA, Hiroshi
内田 浩
HANADA, Masataka
花田 真隆
Title: SOLID PHARMACEUTICAL COMPOSITION
Abstract:
[Problem] Provided is a pharmaceutical composition which suppresses gelation of the 7-{(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride and which suppresses elution delay. [Solution] This solid pharmaceutical composition is obtained by using crystals (B-form crystals) of a hydrate of 7-{(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride, having peaks at 9.4 and 17.7 degrees (±0.2 degrees for each) as 2θ diffraction angles in X-ray powder diffraction using CuKα emission.